Methazolamide
Administration
- Type: Carbonic anhydrase inhibitor, diuretic
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names: Neptazane
Adult Dosing
- 50-100mg PO BID/TID
Pediatric Dosing
Safety/efficacy not established
Special Populations
Pregnancy Rating
- C
Lactation risk
- Not known if enters breastmilk, use caution
Renal Dosing
- Contraindicated in severe impairment
Hepatic Dosing
- Contraindicated in severe impairment
Contraindications
- Allergy to class/drug
- Hypokalemia
- Hyponatremia
- Hyperchloremic acidosis
- Renal/hepatic impairment,severe
- Cirrhosis
- Adrenal insufficiency
- Caution in:
- COPD
- Concomitant high-dose ASA or steroid therapy
- Hepatic insufficiency
Adverse Reactions
Serious
- SJS/TEN
Common
- Drowsiness
- Paresthesias
- Anorexia, nausea/vomiting
- Sulfonamide-type reactions
- Acidosis
- Electrolyte imbalance
- Glycosuria
- Hematuria
- Thrombocytopenia
- Hepatic dysfunction
- Tinnitus
Pharmacology
- Half-life: 14d
- Metabolism:
- Excretion: Urine
Mechanism of Action
- Carbonic anhydrase inhibitor