Methazolamide

Administration

• Type: Carbonic anhydrase inhibitor, diuretic
• Dosage Forms:
• Routes of Administration: PO
• Common Trade Names: Neptazane

Adult Dosing

• 50-100mg PO BID/TID

Pediatric Dosing

Safety/efficacy not established

Special Populations

Pregnancy Rating

• C

Lactation risk

• Not known if enters breastmilk, use caution

Renal Dosing

• Contraindicated in severe impairment

Hepatic Dosing

• Contraindicated in severe impairment

Contraindications

• Allergy to class/drug
• Hypokalemia
• Hyponatremia
• Hyperchloremic acidosis
• Renal/hepatic impairment,severe
• Cirrhosis
• Adrenal insufficiency
• Caution in:
  • COPD
  • Concomitant high-dose ASA or steroid therapy
  • Hepatic insufficiency

Adverse Reactions

Serious

• SJS/TEN

Common

• Drowsiness
• Paresthesias
• Anorexia, nausea/vomiting
• Sulfonamide-type reactions
• Acidosis
• Electrolyte imbalance
• Glycosuria
• Hematuria
• Thrombocytopenia
• Hepatic dysfunction
• Tinnitus

Pharmacology

• Half-life: 14d
• Metabolism:
• Excretion: Urine

Mechanism of Action

• Carbonic anhydrase inhibitor