Methazolamide

Administration

  • Type: Carbonic anhydrase inhibitor, diuretic
  • Dosage Forms:
  • Routes of Administration: PO
  • Common Trade Names: Neptazane

Adult Dosing

  • 50-100mg PO BID/TID

Pediatric Dosing

Safety/efficacy not established

Special Populations

Pregnancy Rating

  • C

Lactation risk

  • Not known if enters breastmilk, use caution

Renal Dosing

  • Contraindicated in severe impairment

Hepatic Dosing

  • Contraindicated in severe impairment

Contraindications

  • Allergy to class/drug
  • Hypokalemia
  • Hyponatremia
  • Hyperchloremic acidosis
  • Renal/hepatic impairment,severe
  • Cirrhosis
  • Adrenal insufficiency
  • Caution in:
    • COPD
    • Concomitant high-dose ASA or steroid therapy
    • Hepatic insufficiency

Adverse Reactions

Serious

  • SJS/TEN


Common

  • Drowsiness
  • Paresthesias
  • Anorexia, nausea/vomiting
  • Sulfonamide-type reactions
  • Acidosis
  • Electrolyte imbalance
  • Glycosuria
  • Hematuria
  • Thrombocytopenia
  • Hepatic dysfunction
  • Tinnitus

Pharmacology

  • Half-life: 14d
  • Metabolism:
  • Excretion: Urine

Mechanism of Action

  • Carbonic anhydrase inhibitor

Comments

See Also

References

Authors: