Miconazole

Administration

  • Type: Antifungal
  • Dosage Forms: 2% Cream
  • Routes of Administration: Topical
  • Common Trade Names: Monistat-Derm, Desenex, Lotrimin, Micatin, Zeasorb

Adult Dosing

Candidiasis, cutaneous

  • Apply 2% Cream BID to affected area x2 weeks

Tinea corporis

  • Apply 2% Cream BID to affected area x4 weeks

Tinea cruris

  • Apply 2% Cream BID to affected area x2 weeks

Tinea pedis

  • Apply 2% Cream BID to affected area x4 weeks

Pediatric Dosing

Candidiasis, cutaneous

  • Apply 2% Cream BID to affected area x2 weeks

Tinea corporis

  • Apply 2% Cream BID to affected area x4 weeks

Tinea cruris

  • Apply 2% Cream BID to affected area x2 weeks

Tinea pedis

  • Apply 2% Cream BID to affected area x4 weeks

Special Populations

Pregnancy Rating

  • Risk of fetal harm no expected
  • May use during pregnancy

Lactation risk

  • May use while breastfeeding

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • May occur, but none reported

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: None, minimal systemic absorption
  • Excretion: None

Mechanism of Action

  • Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis

Comments

See Also

References

Authors:

Jonathan Warren