Misoprostol
General
- Type: Prostaglandin
- Dosage Forms:
- Routes of Administration:
- Common Trade Names: Cytotec
Adult Dosing
Postpartum hemorrhage
- Second Line therapy and can be administered sublingually, orally, vaginally, and rectally.[1]
- 1,000 mcg administered rectally
- 800 mcg PO
Pediatric Dosing
Special Populations
- Pregnancy Rating: X
- Lactation risk: Excreted in breastmilk
- Renal Dosing: not defined
- Hepatic Dosing: not defined
Contraindications
- Allergy to class/drug
- Pregnancy (when used to treat ulcers)
Adverse Reactions
Serious
- Anaphylaxis
- Dysrhythmia, MI
- GI bleed
- Uterine rupture
- Thromboembolic disorder
Common
- Diarrhea, abdominal pain, flatulence, nausea
- Headache
- Anemia
- Chest pain
Pharmacology
- Half-life: 20-40min
- Metabolism: Hepatic
- Excretion:
- Mechanism of Action: Synthetic prostaglandin E analogue
Comments
See Also
References
- ↑ Mousa HA, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2003;(1):CD003249.