Pancuronium
General
- Type: Neuromuscular blocker
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Calculate based on ideal body weight
- Intubation dose: bolus 0.06-0.1 mg/kg IV
- Maintenance: 0.015-0.1 mg/kg IV q30-60min OR continuous infusion: 0.1 mg/kg/hr IV
Pediatric Dosing
- Neonates
- Load: 0.02 mg/kg IV
- Maintenance: 0.05-0.1 mg/kg IV q0.5-4hr PRN
- >1mo
- Load: 0.04-0.1 mg/kg IV
- Maintenance: 0.015-0.1 mg/kg IV q30-60min OR continual infusion: 0.1 mg/kg/hr IV
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown
- Renal Dosing
- CrCl 10-50 mL/min: Administer 50% normal dose
- CrCl <10 mL/min: Do not use
- Hepatic Dosing: Use caution
Contraindications
- Allergy to class/drug or bromides
- Caution if:
- Following opioid, sedative or anesthetic agent (additive/synergistic effects)
- Poor renal perfusion or severe renal disease
- Preexisting tachycardia
- >25% TBSA burns
- HyperMg, hypoK, hypoCa (increased sensitivity)
Adverse Reactions
Serious
- Anaphylaxis
- Tachycardia, dose related
- Bronchospasm
- Hypotension
Common
- Tachycardia
- Hypertension
- Excessive salivation
- Excessive sweating
- Rash
- Wheezing
Pharmacology
- Half-life: 2h
- Metabolism: primarily none
- Excretion: Urinary
- Mechanism of Action: Non-depolarizing skeletal muscle relaxant; cholinergic receptor antagonist