| Syndrome
|
Main causal cancers
|
Mechanism
|
| Cushing syndrome |
Small cell lung cancer, pancreatic carcinoma, neural tumors, thymoma |
Ectopic ACTH/ACTH-like substance production
|
| SIADH |
Small cell lung cancer, CNS malignancies |
Ectopic ADH production
|
| Hypercalcemia |
Lung (esp. SCC), breast, renal/bladder, ovarian, multiple myeloma, adult T cell leukemia/lymphoma, squamous cell carcinoma |
|
| Hypoglycemia |
Sarcomas, insulinoma, hepatocellular carcinoma |
Insulin/IGF production
|
| Carcinoid syndrome |
Bronchial adenoma, pancreatic and gastric carcinoma |
Serotonin or bradykinin production
|
| Hyperaldosteronism |
Adrenal adenoma, non-Hodgkin's lymphoma, ovarian carcinoma, lung cancer |
increased/ectopic aldosterone production
|
| Lambert-Eaton myasthenic syndrome |
Small cell lung cancer |
Immune-mediated
|
| Paraneoplastic cerebellar degeneration |
Lung, ovarian, breast cancers, Hodgkin's lymphoma |
|
| Opsoclonus myoclonus syndrome |
Neuroblastoma (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma |
Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability
|
| Brain-stem or limbic encephalitis |
Small cell lung cancer, germ-cell testicular tumors |
Autoantibodies against intracellular neuronal proteins
|
| Anti-NMDA receptor encephalitis |
Gyn tumors (esp. teratomas) |
Anti-NMDA receptor auto-antibodies
|
| Polymyositis/Dermatomyositis |
Lymphoma, lung, pancreatic, stomach, bladder, ovarian |
autoimmune
|
| Acanthosis nigricans |
Gastric, lung, uterine |
Epidermal growth factor secretion
|
| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, pyoderma gangrenosum, florid cutaneous papillomatosis, necrolytic migratory erythema, hypertrichosis) |
lung, GI adenocarcinomas, breast and GU cancers, lymphoma |
|
| VTE, thrombophlebitis |
any advanced cancer. Pancreatic and bronchogenic carcinomas associated w/trousseau's sign |
Hypercoagulability
|
| Polycythemia |
Renal cell carcinoma, cerebellar hemangioma, hepatocellular carcinoma |
Increased erythropoietin production
|
| Granulocytosis |
various |
C-GSF
|
| Membranous glomerulonephritis |
|
tumor antigens/immune complexes
|
| Thymoma-associated multiorgan autoimmunity |
Thymoma |
similar to GVHD
|
