Propafenone

Administration

  • Type:Antiarrhythmics
  • Dosage Forms: Oral cap, Oral tablet
  • Routes of Administration: PO
  • Common Trade Names: Rhythmol

Adult Dosing

Sustained Ventricular Tachycardia

  • 150 mg PO q 8 hrs
  • Dosage may be increased at 3-4 days to 225 mg PO q 8 hrs
  • Max dosage: 300 mg PO q 8 hrs

New Onset Atrial fibrillation

  • 450 to 600 mg PO as a single dose

Sinus Rhythm Maintenance in Atrial fibrillation or Atrial flutter

  • See sustained VT dosing

PSVT Prophylaxis in AVRT including WPW

  • 300 mg q 8 hrs for 48 hrs (max 900 mg q 8 hrs)
  • Limited data regarding dosing

Pediatric Dosing

PSVT Prophylaxis in AVRT including WPW

  • 8 to 10 mg/kg/day PO in 3 divided doses.
  • Increase by 2 to 3 mg/kg/day every 2 to 3 days
  • Max 15 mg/kg/day PO in 3 divided doses.

Special Populations

Pregnancy Rating

Lactation risk

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • Significant QRS widening
  • High Grade Heart Block
  • Heart Failure
  • Left Ventricular Dysfunction
  • Bradycardia
  • Cardiogenic Shock
  • Electrolyte Imbalance
  • Hypotension
  • Sick Sinus Syndrome
  • Long QT Syndrome
  • Brugada Syndrome
  • Renal failure (relative)
  • Hepatic failure (relative)
  • Asthma
  • COPD
  • Bronchospasm
  • SLE

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:

Mechanism of Action

Comments

See Also

References

Authors: