Remi-fentanil

Administration

  • Type: Synthetic opioid (ultra short acting)
  • Routes of Administration: IV
  • Common Trade Names: ULTIVA

Adult Dosing

  • 1mcg/kg bolus for acute pain
  • .25-5 mcg/kg/hr (titrate q20min) for maintenance analgesia

Pediatric Dosing

  • 1mcg/kg bolus for acute pain
  • .25-5 mcg/kg/hr (titrate q20min) for maintenance analgesia

Special Populations

Pregnancy Rating

  • Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome

Lactation risk

  • Risk is unknown

Renal Dosing

  • Adult: Pharmacodynamics are not affected by renal dysfunction
  • Pediatric: Pharmacodynamics are not affected by renal dysfunction

Hepatic Dosing

  • Adult: Pharmacodynamics are not affected by liverdysfunction
  • Pediatric: Pharmacodynamics are not affected by renal dysfunction

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Respiratory depression

Common

  • Respiratory depression for large doses dependent on body weight.

Pharmacology

  • Half-life: 1--20 min
  • Metabolism: plasma and tissue esterases
  • Excretion: NA

Mechanism of Action

Opiod mu receptor agonist that unlike other opioids is plasma metabolized irrespective of hepatic function.

Comments

See Also

References