SGLT-2 Inhibitor

Administration

  • Type: Oral Diabetes medication
  • Canagliflozin (Invokana), Dapagliflozin (Farxiga), Empagliflozin (Jardiance) are FDA approved for use in type 2 diabetes

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • UTI
  • Genital candidiasis
  • Weight loss
  • Dehydration/Orthostasis

Mechanism of Action

  • Inhibit sodium-glucose cotransporter 2, decreasing glucose reabsorption in the proximal tubule

References