Sarilumab

Administration

• Type:
• Dosage Forms:
• Routes of Administration:
• Common Trade Names:

Adult Dosing

COVID

• Use the single-dose, prefilled syringe (not the prefilled pen) for SQ injection
• Reconstitute sarilumab 400 mg in 100 cc 0.9% NaCl and administer as an IV infusion over 1 hour

Special Populations

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

Comments

• Use as an alternative immunomodulatory drug if tocilizumab is not available or not feasible to use (BIIa).
• In the United States, the currently approved route of administration for sarilumab is SQ injection. In the REMAP-CAP trial, the SQ formulation was used to prepare the IV infusion.