Sodium polystyrene sulfonate

General

  • Type:
  • Dosage Forms:
  • Common Trade Names: Kayexylate

Adult Dosing

Hyperkalemia

  • 30 gm oral or per rectum

Pediatric Dosing

  • >1mo: 1 g/kg PO or PR q6hr PRN

Special Populations

  • Pregnancy Rating: B
  • Lactation: Not absorbed systemically so infant risk minimal
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug
  • Hypokalemia
  • Obstructive bowel disease, reduced gut motility
  • Rectal administration in neonates, particularly if premature

Adverse Reactions

Serious

  • Intestinal necrosis, ulceration, perforation, fecal impaction
  • Bezoars

Common

  • Abdominal pain, nausea/vomiting, constipation, GI disturbance
  • Hypokalemia
  • Hypocalcemia
  • Hypomagnesemia
  • Sodium retention

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action: Cation exchange resin, sodium ions partially released from polystyrene and replaced by potassium

See Also

References