Sucralfate
Administration
- Type:
- Dosage Forms: suspension, tablet
- Routes of Administration: PO
- Common Trade Names: Carafate
Adult Dosing
- Duodenal ulcer
- Active ulcer treatment: 1g PO 4 times daily x 4-8 weeks
- Maintenance therapy: 1g twice daily
Pediatric Dosing
- Peptic ulcer disease: 40-80 mg/kg/day divided q6 hours, maximum 1000mg/dose
- Esophagitis
- 3 months-6 years of age: 500mg PO 4 times daily
- >6 years: 1000mg/dose four times daily
Special Populations
Pregnancy Rating
- B: Acceptable for use in pregnancy
Lactation risk
- Use considered acceptable
Renal Dosing
- Use caution in chronic renal failure or dialysis due to absorption of aluminum salts
Hepatic Dosing
- No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anaphylaxis
- Bronchospasm, laryngeal/pharyngeal/pulmonary edema
Common
- Constipation
Pharmacology
Acts locally in GI tract, minimally absorbed
- Half-life:
- Metabolism: none
- Excretion:
Mechanism of Action
- Binds to form complex with positively charged proteins in exudates, forming a viscous paste-like adhesive substance, which then selectively forms a protective coating that protects gastric lining against peptic acid, pepsin, and bile salts
Comments
See Also
References
Uptodate