Sucralfate

Administration

  • Type:
  • Dosage Forms: suspension, tablet
  • Routes of Administration: PO
  • Common Trade Names: Carafate

Adult Dosing

  • Duodenal ulcer
    • Active ulcer treatment: 1g PO 4 times daily x 4-8 weeks
    • Maintenance therapy: 1g twice daily

Pediatric Dosing

  • Peptic ulcer disease: 40-80 mg/kg/day divided q6 hours, maximum 1000mg/dose
  • Esophagitis
    • 3 months-6 years of age: 500mg PO 4 times daily
    • >6 years: 1000mg/dose four times daily

Special Populations

Pregnancy Rating

  • B: Acceptable for use in pregnancy

Lactation risk

  • Use considered acceptable

Renal Dosing

  • Use caution in chronic renal failure or dialysis due to absorption of aluminum salts

Hepatic Dosing

  • No adjustment

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Anaphylaxis
  • Bronchospasm, laryngeal/pharyngeal/pulmonary edema

Common

  • Constipation

Pharmacology

Acts locally in GI tract, minimally absorbed

  • Half-life:
  • Metabolism: none
  • Excretion:

Mechanism of Action

  • Binds to form complex with positively charged proteins in exudates, forming a viscous paste-like adhesive substance, which then selectively forms a protective coating that protects gastric lining against peptic acid, pepsin, and bile salts

Comments

See Also

References

Uptodate