Sucralfate

Administration

• Type:
• Dosage Forms: suspension, tablet
• Routes of Administration: PO
• Common Trade Names: Carafate

Adult Dosing

• Duodenal ulcer
  • Active ulcer treatment: 1g PO 4 times daily x 4-8 weeks
  • Maintenance therapy: 1g twice daily

Pediatric Dosing

• Peptic ulcer disease: 40-80 mg/kg/day divided q6 hours, maximum 1000mg/dose
• Esophagitis
  • 3 months-6 years of age: 500mg PO 4 times daily
  • >6 years: 1000mg/dose four times daily

Special Populations

Pregnancy Rating

• B: Acceptable for use in pregnancy

Lactation risk

• Use considered acceptable

Renal Dosing

• Use caution in chronic renal failure or dialysis due to absorption of aluminum salts

Hepatic Dosing

• No adjustment

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Anaphylaxis
• Bronchospasm, laryngeal/pharyngeal/pulmonary edema

Common

• Constipation

Pharmacology

Acts locally in GI tract, minimally absorbed

• Half-life:
• Metabolism: none
• Excretion:

Mechanism of Action

• Binds to form complex with positively charged proteins in exudates, forming a viscous paste-like adhesive substance, which then selectively forms a protective coating that protects gastric lining against peptic acid, pepsin, and bile salts

See Also

• peptic ulcer disease

References

Uptodate