Template:Cryptococcus Meningitis

Meningitis (not AIDs associated)

• Amphotericin B 0.7-1mg/kg IV q24hrs AND Flucytosine 25mg/kg PO q6hrs x 4 weeks
  • Followed by Fluconazole 400mg PO q24hrs x 8 weeks

Meningitis (with AIDS)

• Amphotericin B 0.7-1mg/kg IV q24hrs AND Flucytosine 25mg/kg PO q6hrs x 2 weeks
  • Followed by Fluconazole 400mg PO q24hrs x 8 weeks
• Initiation of HAART is delayed by 2 to 10 weeks to minimize the risk of immune reconstitution syndrome

Pediatric Cryptococcal Meningitis

• Amphotericin B 0.7-1mg/kg IV daily x 2-4 weeks + Flucytosine 25mg/kg PO q6hrs
  • Followed by Fluconazole 6-12mg/kg PO daily x 8 weeks (max 400mg)