Template:Heparin reversal

• Major bleeding due to unfractionated heparin:
  • 1 mg IV for every 100 units of heparin infused in past 3h
  • Do not infuse faster than 50mg/10min
  • If it has been >30min since last heparin injection, 0.5mg may be sufficient
  • Give slowly over 1-3min; do not exceed 50mg in any 10 minute period (anaphylaxis risk)
  • Because half-life is short (7 min) may require second treatment
• Major bleeding due to low-molecular-weight heparin:
  • Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds
  • Enoxaparin: 1 mg IV for every 1 mg enoxaparin administered in past 8h
  • Dalteparin: 1 mg IV for every 100 anti-Xa international units of dalteparin