Template:Rocky Mountain Spotted Fever antibiotics
- Doxycycline 100mg PO BID x 5-7 days[1]
- Indicated also in children at 2.2mg/kg BID
- Chloramphenicol 50-100mg/kg/day div q6hrs (max 4g/day)
- Preferred agent in pregnancy. May cause aplastic anemia and Grey baby syndrome, more common in near term or 3rd trimester[2]
- Consideration should be made for doxycycline over CAM in the 3rd trimester
Pediatric
Doxycycline is the first-line treatment for RMSF in children of ALL ages per CDC and AAP
- Doxycycline 2.2mg/kg PO/IV BID (max 100mg/dose) x 5-7 days or until afebrile x 3 days
- Chloramphenicol 50-100mg/kg/day IV divided q6hrs (max 4g/day) if doxycycline allergy
- ↑ Shandera WX, Roig IL: Viral & Rickettsial Infections, in Papadakis MA, McPhee SJ (eds): Current Medical Diagnosis and Treatment, ed 52. USA, McGraw-Hill, 2013, (Ch) 32: p 1412-1413.
- ↑ http://www.cdc.gov/rmsf/