Template:Toxoplasmosis Antibiotics

Immunocompetent

Antibiotics only needed if patient has severe symptoms

Immunosprepressed

Pregnant

  • Spiramycin 1 g orally every 8 hours[1]
    • If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
    • Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
  • Pyrimethamine (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
    • Leucovorin 10-25 mg/day orally to prevent bone marrow suppression
  • Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.