Chlorate toxicity: Difference between revisions
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*Fireworks, match heads, and weed killers | *Fireworks, match heads, and weed killers | ||
==Mechanism of Toxicity== | ===Mechanism of Toxicity=== | ||
*Oxidizers and attackers of sulfhydryl groups | *Oxidizers and attackers of sulfhydryl groups | ||
*Cause methemoglobin formation | *Cause methemoglobin formation | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
*Abdominal | *[[Abdominal pain]] | ||
*Vomiting | *[[Vomiting]] | ||
*Diarrhea | *[[Diarrhea]] | ||
*Methemoglobinemia | *[[Methemoglobinemia]] | ||
*Coagulopathy | *[[Coagulopathy]] | ||
==Differential Diagnosis== | |||
==Diagnosis== | ==Diagnosis== | ||
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==Management== | ==Management== | ||
*Activated charcoal IS recommended | *[[Activated charcoal]] IS recommended | ||
*Methylene | *[[Methylene blue]] for [[methemoglobinemia]] (1-2 mg/kg of 1% solution) | ||
*Sodium | *[[Sodium thiosulfate]] IV may inactivate chlorate ions (anecdotal) | ||
*Hemodialysis | *Hemodialysis | ||
*Supportive Care | *Supportive Care | ||
==Disposition== | |||
==External Links== | ==External Links== | ||
Revision as of 04:50, 10 April 2017
Background
- Potassium Chlorate, Barium Chlorate, and Sodium Chlorate are still in use today
- Fireworks, match heads, and weed killers
Mechanism of Toxicity
- Oxidizers and attackers of sulfhydryl groups
- Cause methemoglobin formation
Clinical Presentation
Differential Diagnosis
Diagnosis
- Based on clinical history and presence of methemoglobinemia
- No specific levels are available
Management
- Activated charcoal IS recommended
- Methylene blue for methemoglobinemia (1-2 mg/kg of 1% solution)
- Sodium thiosulfate IV may inactivate chlorate ions (anecdotal)
- Hemodialysis
- Supportive Care
Disposition
External Links
References
Olson, K. Poisoning and Drug Overdose, 1999.