Retinoic acid syndrome: Difference between revisions
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==Background== | ==Background== | ||
*Differentiation syndrome (DS) is most current term | |||
*Occurs in [[AML|Acute promyelocytic leukemia]] patients undergoing ATRA treatment (Tretinoin, Vesanoid) | |||
**And/or with arsenic trioxide therapy (Trisenox, ATO) | |||
**Chemo treatment differentiates APML blasts into mature granulocytes | |||
**Differentiation of blasts may cause [[sepsis]]-like "cytokine storm" leading to tissue damage | |||
*Incidence of DS<ref>Montesinos P and Sanz MA. The Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia: Experience of the Pethema Group and Review of the Literature. Mediterr J Hematol Infect Dis. 2011; 3(1): e2011059.</ref> | |||
**Up to 25% of patients undergoing ATRA | |||
**Up to 31% of patients undergoing ATO | |||
*Up to 40% mortality in patients requiring mechanical ventilation | |||
*Diagnosis made clinically with symptomology | |||
**Requires immediate treatment with steroids | |||
**Steroids highly recommended even if other diagnoses possible | |||
== | ==Clinical Features== | ||
*Unexplained [[fever]] | |||
*Unexplained [[hypotension]] | |||
*Weight gain > 5 kg | |||
*[[Dyspnea]] with pulmonary infiltrates | |||
*[[Pericardial effusion]] | |||
*[[Pleural effusion]] | |||
*[[Renal failure]] | |||
*Vascular capillary leak syndrome | |||
*[[DIC]] | |||
*Never observed beyond induction therapy, when patient has achieved complete response | |||
==Differential Diagnosis== | |||
*[[Sepsis]] | |||
*[[Fungal infection]] | |||
*[[diffuse alveolar hemorrhage|Pulmonary hemorrhage]] | |||
*[[Pneumonia]] | |||
*[[Renal failure]] | |||
*[[CHF]] | |||
*[[Pulmonary embolism]] | |||
*[[DIC]] | |||
{{Template:Oncologic emergencies DDX}} | |||
==Evaluation== | |||
*Ultimately, a clinical diagnosis | |||
*[[Troponins]] for [[pericarditis]] | |||
*Severe [[leukocytosis]] on CBC | |||
*[[Sepsis]] workup | |||
*[[CHF]] workup, echo | |||
*[[Pulmonary embolism]] workup | |||
*[[DIC]] workup | |||
*Coagulation factor levels | |||
*Diagnostic bronchoscopy, BAL, biopsy usually not required | |||
*Imaging | |||
**[[CXR]] - pleural effusions, ground-glass opacities, increased cardiac silhouette | |||
**CT chest - pleural effusions, peripheral nodules | |||
==Management<ref>Sanz MA and Montesinos P. How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia. May 1, 2014; Blood: 123 (18).</ref>== | |||
*[[Dexamethasone]] 10mg IV q12hrs | |||
**Most important therapy, with possible dramatic and rapid resolution of symptoms | |||
**Continue treatment until complete disappearance of signs and symptoms | |||
*Temporary discharge ATRA or ATO only in severe cases of DS (renal failure or ICU admit) | |||
*Supportive | |||
**[[Mechanical ventilation]] for respiratory failure | |||
**Careful [[IVF]] admin, prioritizing [[blood products]] for coagulopathies (DIC) | |||
**[[Furosemide]] for fluid overload | |||
**CRRT/[[hemodialysis|HD]] for refractory renal failure | |||
**[[Vasopressors]] | |||
**Empiric [[antibiotics]] | |||
**''Avoid'' invasive pleural/pericardial effusion diagnostics | |||
==Disposition== | |||
*Admit | |||
==See Also== | |||
==External Links== | |||
==References== | |||
<references/> | <references/> | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 17:56, 1 October 2019
Background
- Differentiation syndrome (DS) is most current term
- Occurs in Acute promyelocytic leukemia patients undergoing ATRA treatment (Tretinoin, Vesanoid)
- And/or with arsenic trioxide therapy (Trisenox, ATO)
- Chemo treatment differentiates APML blasts into mature granulocytes
- Differentiation of blasts may cause sepsis-like "cytokine storm" leading to tissue damage
- Incidence of DS[1]
- Up to 25% of patients undergoing ATRA
- Up to 31% of patients undergoing ATO
- Up to 40% mortality in patients requiring mechanical ventilation
- Diagnosis made clinically with symptomology
- Requires immediate treatment with steroids
- Steroids highly recommended even if other diagnoses possible
Clinical Features
- Unexplained fever
- Unexplained hypotension
- Weight gain > 5 kg
- Dyspnea with pulmonary infiltrates
- Pericardial effusion
- Pleural effusion
- Renal failure
- Vascular capillary leak syndrome
- DIC
- Never observed beyond induction therapy, when patient has achieved complete response
Differential Diagnosis
Oncologic Emergencies
Related to Local Tumor Effects
- Malignant airway obstruction
- Bone metastases and pathologic fractures
- Malignant spinal cord compression
- Malignant Pericardial Effusion and Tamponade
- Superior vena cava syndrome
Related to Biochemical Derangement
- Hypercalcemia of malignancy
- Hyponatremia due to SIADH
- Adrenal insufficiency
- Tumor lysis syndrome
- Carcinoid syndrome
Related to Hematologic Derangement
Related to Therapy
- Chemotherapy-induced nausea and vomiting
- Cytokine release syndrome
- Chemotherapeutic drug extravasation
- Differentiation syndrome (retinoic acid syndrome) in APML
- Stem cell transplant complications
- Catheter-related complications
- Tunnel infection
- Exit site infection
- CVC obstruction (intraluminal or catheter tip thrombosis)
- Catheter-related venous thrombosis
- Fracture of catheter lumen
- Oncologic therapy related adverse events
Evaluation
- Ultimately, a clinical diagnosis
- Troponins for pericarditis
- Severe leukocytosis on CBC
- Sepsis workup
- CHF workup, echo
- Pulmonary embolism workup
- DIC workup
- Coagulation factor levels
- Diagnostic bronchoscopy, BAL, biopsy usually not required
- Imaging
- CXR - pleural effusions, ground-glass opacities, increased cardiac silhouette
- CT chest - pleural effusions, peripheral nodules
Management[2]
- Dexamethasone 10mg IV q12hrs
- Most important therapy, with possible dramatic and rapid resolution of symptoms
- Continue treatment until complete disappearance of signs and symptoms
- Temporary discharge ATRA or ATO only in severe cases of DS (renal failure or ICU admit)
- Supportive
- Mechanical ventilation for respiratory failure
- Careful IVF admin, prioritizing blood products for coagulopathies (DIC)
- Furosemide for fluid overload
- CRRT/HD for refractory renal failure
- Vasopressors
- Empiric antibiotics
- Avoid invasive pleural/pericardial effusion diagnostics
Disposition
- Admit
See Also
External Links
References
- ↑ Montesinos P and Sanz MA. The Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia: Experience of the Pethema Group and Review of the Literature. Mediterr J Hematol Infect Dis. 2011; 3(1): e2011059.
- ↑ Sanz MA and Montesinos P. How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia. May 1, 2014; Blood: 123 (18).