Drug fever: Difference between revisions
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==Differential Diagnosis== | ==Differential Diagnosis== | ||
[[ | ===[[Fever]]=== | ||
====Infectious==== | |||
*Critical | |||
**[[Sepsis]] | |||
**[[PNA]] with respiratory failure | |||
** Peritonitis | |||
** [[Meningitis]] | |||
** [[Cavernous Sinus Thrombosis]] | |||
** [[Necrotizing Fasciitis]] | |||
*Emergent | |||
** [[PNA]] | |||
** [[Peritonsillar Abscess]] | |||
** [[Retropharyngeal Abscess]] | |||
** [[Epiglottitis]] | |||
** [[Endocarditis]] | |||
** [[Pericarditis]] | |||
** [[Appendicitis]] | |||
** [[Cholecystitis]] | |||
** [[Diverticulitis]] | |||
** Intra-abdominal abscess | |||
** [[Pyelonephritis]] | |||
** [[Tubo-ovarian abscess]] | |||
** [[Encephalitis]] | |||
** Brain abscess | |||
** [[Cellulitis]] | |||
** [[Abscess]] | |||
** [[Malaria]] | |||
*Non-emergent | |||
**[[Viral syndrome]] | |||
** [[Otitis Media]] | |||
** [[Sinusitis]] | |||
** [[Pharyngitis]] | |||
** [[Influenza]] | |||
** [[TB]] | |||
** [[UTI]] | |||
** [[Epididymitis]] | |||
** [[Prostatitis]] | |||
====Non-infectious==== | |||
*Critical | |||
** [[AMI]] | |||
** [[PE]] | |||
** [[Intracranial Hemorrhage]] | |||
** [[CVA]] | |||
** [[NMS]] | |||
** [[Thyroid Storm]] | |||
** [[Acute Adrenal Insufficiency]] | |||
** [[Transfusion Rx]] | |||
** [[Pulmonary Edema]] | |||
** [[Heat Stroke]] | |||
** [[Malignant hyperthermia]] | |||
*Emergent | |||
** [[CHF]] | |||
** [[Dehydration]] | |||
** Recent [[Seizure]] | |||
** [[Sickle Cell Dz]] | |||
** Transplant rejection | |||
** [[Pancreatitis]] | |||
** [[DVT]] | |||
** [[Serotonin Syndrome]] | |||
*Non-emergent | |||
** [[Drug fever]] (except as in [[NMS]] and [[Serotonin Syndrome]]) | |||
** Malignancy | |||
** [[Gout]] | |||
** Sarcoidosis | |||
** [[Crohn's Disease]] | |||
** Postmyocardiotomy sy | |||
==Evaluation== | ==Evaluation== | ||
Revision as of 18:50, 13 January 2021
Background
Drug fever, or Drug-induced hyperthermia, is an adverse reaction to a drug in which the recipient of the drug develops a fever in direct response to receiving a specific drug. There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen. [1]
Clinical Features
Differential Diagnosis
Fever
Infectious
- Critical
- Sepsis
- PNA with respiratory failure
- Peritonitis
- Meningitis
- Cavernous Sinus Thrombosis
- Necrotizing Fasciitis
- Emergent
- PNA
- Peritonsillar Abscess
- Retropharyngeal Abscess
- Epiglottitis
- Endocarditis
- Pericarditis
- Appendicitis
- Cholecystitis
- Diverticulitis
- Intra-abdominal abscess
- Pyelonephritis
- Tubo-ovarian abscess
- Encephalitis
- Brain abscess
- Cellulitis
- Abscess
- Malaria
- Non-emergent
Non-infectious
- Critical
- Emergent
- CHF
- Dehydration
- Recent Seizure
- Sickle Cell Dz
- Transplant rejection
- Pancreatitis
- DVT
- Serotonin Syndrome
- Non-emergent
- Drug fever (except as in NMS and Serotonin Syndrome)
- Malignancy
- Gout
- Sarcoidosis
- Crohn's Disease
- Postmyocardiotomy sy
Evaluation
Workup
Diagnosis
Management
Disposition
See Also
External Links
References
- ↑ Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021