Diarrhea (peds): Difference between revisions

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==Treatment==
{{Peds top}} [[diarrhea]]
==Background==
[[File:Figure 34 01 10f.png|thumb|Gasterointestinal anatomy.]]
[[File:Layers of the GI Tract english.png|thumb|Layers of the Alimentary Canal. The wall of the alimentary canal has four basic tissue layers: the mucosa, submucosa, muscularis, and serosa.]]
*85% of diarrhea is infectious in etiology
**[[Viruses]] cause vast majority of infectious diarrhea
**[[Bacteria]]l causes are responsible for most cases of severe diarrhea
***Foreign travel associated with 80% probability of bacterial diarrhea (see [[Traveler's Diarrhea]])


===Definitions===
*[[Diarrhea]]: Increased frequency of defection, usually >3 bowel movements per day
*Hyperacute: 1-6 hr
*Acute: less than 3 weeks in duration
*[[Gastroenteritis]]: Diarrhea with nausea and/or vomiting
*Dysentery: Diarrhea with blood/mucus/pus
*Invasive = Infectious


<10yr old
==Clinical Features==
[[File:BristolStoolChart.png|thumb|Bristol Stool Chart.]]
===History===
*Possible food poisoning?
**Symptoms occur within 6hr
*Does it resolve (osmotic) or persist (secretory) with fasting?
*Are the stools of smaller volume (large intestine) or larger volume (small intestine)
*[[Fever]] or [[abdominal pain]]? ([[diverticulitis]], [[gastroenteritis]], [[IBD]])
*[[GI bleeding|Bloody or melenic]]?
*Tenesmus? ([[shigella]])
*Malodorous? ([[giardia]])
*Recent travel? ([[Traveler's Diarrhea]])
*Recent antibiotics? ([[C. diff]])
*[[HIV]]/immunocompromised/high risk behaviors?
*Heat intolerance and anxiety? ([[thyrotoxicosis]])
*[[Paresthesias]] or reverse temperature sensation? ([[Ciguatera]])


<3mo --> abx
===Physical Exam===
*[[Thyroid]] masses
*Oral ulcers, erythema nodosum, episcleritis, [[anal fissure]] ([[IBD]])
*[[Reactive arthritis]] ([[Arthritis]], [[conjunctivitis]], urethritis)
**Suggests infection with [[salmonella]], [[shigella]], [[campylobacter]], or [[yersinia]]


==Differential Diagnosis==
===Infection===
*Viral
**[[Rotavirus]]
**[[Norovirus]], Norwalk virus
**[[Enterovirus]]
**[[Adenovirus]]
*Bacterial
**[[Salmonella]]
**[[Shigella]]
**[[Yersinia]]
**[[Campylobacter]]
**[[Escherichia coli]]
**[[Vibrio]] species
**[[Clostridium difficile]]
**[[TB]]
*Parasitic
**[[Giardia]]
**[[Entamoeba]]
**[[Cryptosporidium]]


Diarrheal Pathogens in Children and Specific Therapy
===Dietary disturbances===
*Overfeeding
*Food [[allergic reaction|allergy]]
*Starvation stools


AGENTSPECIFIC THERAPY BEYOND SUPPORTIVE CARE
===Anatomic abnormalities===
Campylobacter jejuni Azithromycin 12 mg/kg/day PO for 5 days or
*[[Intussusception]]
Erythromycin 30–50 mg/kg/day, divided, tid PO for 5–7 days
*[[Hirschsprung's disease]]
Clostridium difficile Metronidazole 30 mg/kg/day, divided, qid PO for 7–10 days or
*Partial [[SBO]]
Escherichia coli Azithromycin 12 mg/kg/day PO for 5 days or
*[[Appendicitis]]
Trimethoprim-sulfamethoxazole 10 mg (TMP)/kg/day PO divided bid for 5–7 days
*Blind loop syndrome
Giardia lamblia Metronidazole 15 mg/kg/day PO, divided, tid for 5 days
*Intestinal lymphangiectasia
Salmonella species In toxic infants <3 mo:Ampicillin 200 mg/kg/24 hours q6h for 7–10 days andGentamicin 5–7.5 mg/kg/24 hours q8h IV
*[[Short bowel syndrome]]
Shigella species Azithromycin 12 mg/kg/day PO for 5 days or
Trimethoprim-sulfamethoxazole 10 mg (TMP)/kg/day, divided, bid for 5–7 days if susceptible
Yersinia enterocolitica If patient is immunosuppressed, treat as for presumed sepsis
Vibrio None; severe diarrhea or cholera may benefit from antibiotics


==See Also==
===Malabsorption or secretory diseases===
*[[Cystic fibrosis]]
*Celiac disease
*Disaccharidase deficiency
*Secretory neoplasms


===Systemic diseases===
*Immunodeficiency
*Endocrinopathy
**[[Hyperthyroidism]]
**[[Hypoparathyroidism]]
**[[Congenital adrenal hyperplasia]]


Peds: Dehydration
===Miscellaneous===
*[[Inflammatory bowel disease]]
*[[Antibiotic]]-associated diarrhea
*Secondary lactase deficiency
*Irritable colon syndrome
*[[Neonatal abstinence syndrome]]
*[[Toxins]]
*[[Hemolytic uremic syndrome]] (HUS)


==Evaluation==


==Sources==
==Management==
 
===General Treatment===
 
*[[Reduced-osmolarity oral rehydration solution]]
Rosen's
*If [[rectal bleeding|bloody diarrhea]], use caution with beginning antibiotics in ED before stool culture results
*Some studies demonstrate antibiotic treatment in setting of ''[[E.coli]]'' O157:H7 leads to increasing risk of [[hemolytic uremic syndrome]] (HUS)


===Diarrheal Pathogens in Children and Specific Therapy===


{| class="wikitable"
|-
! align="left" | AGENT
! align="left" | SPECIFIC THERAPY BEYOND SUPPORTIVE CARE
|-
| align="left" rowspan="2" | ''[[Campylobacter jejuni]]''
| align="left" | [[Azithromycin]] 12mg/kg/day PO for 5 days ''or''
|-
| align="left" | [[Erythromycin]] 30–50mg/kg/day, divided, tid PO for 5–7 days
|-
| align="left" | ''[[Clostridium difficile]]''
| align="left" | [[Metronidazole]] 30mg/kg/day, divided, QID PO for 7–10 days ''or''
|-
| align="left" rowspan="2" | ''[[Escherichia coli]]''
| align="left" | [[Azithromycin]] 12mg/kg/day PO for 5 days ''or''
|-
| align="left" | [[Trimethoprim-sulfamethoxazole]] 10mg (TMP)/kg/day PO divided BID for 5–7 days
|-
| align="left" | ''[[Giardia]]'' lamblia
| align="left" | [[Metronidazole]] 15mg/kg/day PO, divided, tid for 5 days
|-
| align="left" | ''[[Salmonella]]'' species
| align="left" | ''In toxic infants <3'' ''mo''<nowiki>:</nowiki><br>[[Ampicillin]] 200mg/kg/24 hours q6h for 7–10 days ''and''<br>[[Gentamicin]] 5–7.5mg/kg/24 hours q8h IV
|-
| align="left" rowspan="2" | ''Shigella'' species
| align="left" | [[Azithromycin]] 12mg/kg/day PO for 5 days ''or''
|-
| align="left" | [[Trimethoprim-sulfamethoxazole]] 10mg (TMP)/kg/day, divided, BID for 5–7 days if susceptible
|-
| align="left" | ''[[Yersinia enterocolitica]]''
| align="left" | If patient is immunosuppressed, treat as for presumed sepsis
|-
| align="left" | ''[[Vibrio cholera]]''
| align="left" | None; severe diarrhea or cholera may benefit from antibiotics
|}


==See Also==
*[[Diarrhea]]
*[[Dehydration (peds)]]
*[[Nausea and vomiting (peds)]]
*[[Acute gastroenteritis (peds)]]


[[Category:Peds]]
==References==
<references/>
[[Category:Pediatrics]] [[Category:ID]] [[Category:GI]] [[Category:Symptoms]]

Latest revision as of 16:00, 29 January 2025

This page is for pediatric patients. For adult patients, see: diarrhea

Background

Gasterointestinal anatomy.
Layers of the Alimentary Canal. The wall of the alimentary canal has four basic tissue layers: the mucosa, submucosa, muscularis, and serosa.
  • 85% of diarrhea is infectious in etiology
    • Viruses cause vast majority of infectious diarrhea
    • Bacterial causes are responsible for most cases of severe diarrhea

Definitions

  • Diarrhea: Increased frequency of defection, usually >3 bowel movements per day
  • Hyperacute: 1-6 hr
  • Acute: less than 3 weeks in duration
  • Gastroenteritis: Diarrhea with nausea and/or vomiting
  • Dysentery: Diarrhea with blood/mucus/pus
  • Invasive = Infectious

Clinical Features

Bristol Stool Chart.

History

Physical Exam

Differential Diagnosis

Infection

Dietary disturbances

  • Overfeeding
  • Food allergy
  • Starvation stools

Anatomic abnormalities

Malabsorption or secretory diseases

  • Cystic fibrosis
  • Celiac disease
  • Disaccharidase deficiency
  • Secretory neoplasms

Systemic diseases

Miscellaneous

Evaluation

Management

General Treatment

Diarrheal Pathogens in Children and Specific Therapy

AGENT SPECIFIC THERAPY BEYOND SUPPORTIVE CARE
Campylobacter jejuni Azithromycin 12mg/kg/day PO for 5 days or
Erythromycin 30–50mg/kg/day, divided, tid PO for 5–7 days
Clostridium difficile Metronidazole 30mg/kg/day, divided, QID PO for 7–10 days or
Escherichia coli Azithromycin 12mg/kg/day PO for 5 days or
Trimethoprim-sulfamethoxazole 10mg (TMP)/kg/day PO divided BID for 5–7 days
Giardia lamblia Metronidazole 15mg/kg/day PO, divided, tid for 5 days
Salmonella species In toxic infants <3 mo:
Ampicillin 200mg/kg/24 hours q6h for 7–10 days and
Gentamicin 5–7.5mg/kg/24 hours q8h IV
Shigella species Azithromycin 12mg/kg/day PO for 5 days or
Trimethoprim-sulfamethoxazole 10mg (TMP)/kg/day, divided, BID for 5–7 days if susceptible
Yersinia enterocolitica If patient is immunosuppressed, treat as for presumed sepsis
Vibrio cholera None; severe diarrhea or cholera may benefit from antibiotics

See Also

References

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