Histoplasmosis: Difference between revisions

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==Background==
==Background==
[[File:Histo-xray.png|thumb|Histoplasmosis after return from Pennsylvania, United States]]
*Fungal infection caused by ''Histoplasma capsulatum''<ref>Lowell JR. Diagnosis of histoplasmosis. Ann Intern Med. Feb 1983;98(2):260</ref>
*Fungal infection caused by Histoplasma capsulatum<ref>Lowell JR. Diagnosis of histoplasmosis. Ann Intern Med. Feb 1983;98(2):260</ref>
*Endemic to the Ohio, Missouri, and Mississippi River valleys in the United States<ref>Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008. MMWR Morb Mortal Wkly Rep. Dec 19 2008;57(50):1349-53</ref>
*Endemic to the Ohio, Missouri, and Mississippi River valleys in the United States<ref>Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008. MMWR Morb Mortal Wkly Rep. Dec 19 2008;57(50):1349-53</ref>
*Exposure from disruption of soil containing organisms leads to aerosolization<ref>Hage, Chadi A., and L. Joseph Wheat. "Chapter 199. Histoplasmosis." Harrison's Principles of Internal Medicine, 18e. Eds. Dan L. Longo, et al. New York, NY: McGraw-Hill, 2012. n. pag. AccessMedicine. Web. 4 Dec. 2014</ref>
*Exposure from disruption of soil containing organisms leads to aerosolization<ref>Hage, Chadi A., and L. Joseph Wheat. "Chapter 199. Histoplasmosis." Harrison's Principles of Internal Medicine, 18e. Eds. Dan L. Longo, et al. New York, NY: McGraw-Hill, 2012. n. pag. AccessMedicine. Web. 4 Dec. 2014</ref>
*Activities associated with high-level exposure include spelunking, excavation, and demolition of old buildings<ref>Hage, Chadi A., and L. Joseph Wheat. "Chapter 199. Histoplasmosis." Harrison's Principles of Internal Medicine, 18e. Eds. Dan L. Longo, et al. New York, NY: McGraw-Hill, 2012. n. pag. AccessMedicine. Web. 4 Dec. 2014</ref>
*Activities associated with high-level exposure include spelunking, excavation, and demolition of old buildings
 
[[File:Histo-xray.png|thumb|Histoplasmosis after return from Pennsylvania, United States]]
 
===Pathogenesis===
*Infection occurs via inhalation<ref>“Histoplasmosis.” CDC. (2014, Sept. 25) Web 4 Dec. 2014. http://www.cdc.gov/fungal/diseases/histoplasmosis</ref>
*In immunocompetent patients:
**Phagocytes and epithelial cells eventually organize and form granulomas that go on to fibrose and calcify
*In immunocompromised patients:
**The infection is not contained and can disseminate


==Clinical Features==
==Clinical Features==
*Disease manifestation depends on intensity of exposure, immune status, and underlying lung architecture<ref>Hage, Chadi A., and L. Joseph Wheat. "Chapter 199. Histoplasmosis." Harrison's Principles of Internal Medicine, 18e. Eds. Dan L. Longo, et al. New York, NY: McGraw-Hill, 2012. n. pag. AccessMedicine. Web. 4 Dec. 2014</ref>
''Disease manifestation depends on intensity of exposure, immune status, and underlying lung architecture''
===Acute Pulmonary Histoplasmosis===
===Acute Pulmonary Histoplasmosis===
*90% asymptomatic, and usually self-limited
*90% asymptomatic, and usually self-limited
*Symptoms 1-4 weeks after exposure and consist of flu-like illness  
*Symptoms 1-4 weeks after exposure and consist of flu-like illness<ref>http://www.ncbi.nlm.nih.gov/pubmed/24528944</ref>
**Fever/chills
**Fever/chills
**Headache
**Headache
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*Hilar/mediastinal lymphadenopathy on CXR
*Hilar/mediastinal lymphadenopathy on CXR
===Chronic Pulmonary Histoplasmosis===
===Chronic Pulmonary Histoplasmosis===
*Mostly older patients or smokers with underlying structural lung disease
*Mostly older patients or smokers with underlying structural lung disease<ref>http://www.ncbi.nlm.nih.gov/pubmed/23664715</ref>
*Symptoms:  
*Symptoms:  
**Cough
**Cough
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**Night sweats
**Night sweats
**Sometimes hemoptysis, sputum production, dyspnea
**Sometimes hemoptysis, sputum production, dyspnea
*CXR may show:  
*[[CXR]] may show:  
**Upper lobe infiltrates
**Upper lobe infiltrates
**Fibrosis, scarring
**Fibrosis, scarring
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==Differential Diagnosis==
==Differential Diagnosis==
*Aspergillosis
*[[Carcinoid]] Lung Tumors
*Blastomycosis
*Carcinoid Lung Tumors
*[[Chlamydophila psittaci]]
*[[Coccidioidomycosis]]
*[[Legionella]] pneumonias
*Lung Cancer, Small Cell
*Lung Cancer, Small Cell
*Lymphoma, Mediastinal
*Lymphoma, Mediastinal
*Mediastinal Cysts
*Mediastinal Cysts
*[[Lung Abscess]]
*[[Lung Abscess]]
*[[Mycoplasma pneumoniae|Mycoplasma Infections]]
*[[Pancoast Syndrome]]
*Pancoast Syndrome
*Pneumococcal Infections
*Pneumocystis Carinii Pneumonia
*[[Aspiration Pneumonia]]
*[[Pneumonia]]  
*[[Sarcoidosis]]
*[[Sarcoidosis]]
*[[Tuberculosis]]
*[[Tuberculosis]]


==Workup==
{{Causes of pneumonia}}
*CXR
 
==Evaluation==
===Workup===
*[[CXR]]
**Normal in 40-70% of cases
**Normal in 40-70% of cases
**Pneumonitis with hilar adenopathy
**Pneumonitis with hilar adenopathy
**Focal pulmonary infiltrates with light exposure
**Focal pulmonary infiltrates with light exposure
**Diffuse infiltrates with heavy exposure
**Diffuse infiltrates with heavy exposure
*CBC (mild anemia in chronic disease)
*CBC - mild anemia in chronic disease
*Alkaline phosphatase (elevated in disseminated and chronic disease)
*Liver panel - alkaline phosphatase elevated in disseminated and chronic disease
*LDH (elevated in AIDS patients with disseminated disease)
*LDH - elevated in AIDS patients with disseminated disease
*Definitive diagnosis by:
*Definitive diagnosis by:
**Sputum cultures
**Sputum cultures
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**Antibody testing
**Antibody testing
**Serum/urine antigen testing
**Serum/urine antigen testing
*Further imaging if concerned for specific organ involvement in disseminated disease (head CT, abdominal CT or lumbar puncture)
*Further imaging if concerned for specific organ involvement in disseminated disease (Head CT, Abdominal CT or [[Lumbar puncture]])


==Treatment==
==Management==
===Acute Pulmonary Histoplasmosis===
===Acute Pulmonary Histoplasmosis===
*Do not treat if asymptomatic
*Do not treat if asymptomatic
*Itraconazole x 6-12 weeks<ref>Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807-825</ref>
**Not progressive, resolves without treatment, only rarely reactivates
*Severe disease: Amphotericin B x 1 week then Itraconazole x 1 year<ref>Hospenthal DR, Becker SJ. Update on Therapy for Histoplasmosis. Infect Med. April 13 2009;26:121-124</ref>
===Progressive Disseminated Histoplasmosis===
*Pulmonary cases: Itraconazole x 6-12 weeks<ref>Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807-825</ref>
*Severe disease: [[Amphotericin B]] x 1 week then Itraconazole x 1 year<ref>Hospenthal DR, Becker SJ. Update on Therapy for Histoplasmosis. Infect Med. April 13 2009;26:121-124</ref>
*Surgical intervention may be necessary in some cases


===Chronic Pulmonary Histoplasmosis===
===Chronic Pulmonary Histoplasmosis===
*Itraconazole x 1 year
*[[Itraconazole]] x 1 year
===Progressive Disseminated Histoplasmosis===
 
*See above medical therapy
==Disposition==
*Surgical intervention may be needed for some end organ involvement
*Discharge asymptomatic cases
==Sources==
*Discharge mildly symptomatic immunocompetent patients with primary care follow up
*Admit severe symptoms or symptomatic immunocompromised patients
 
==See Also==
*[[Fungal infections]]
*[[Antifungals]]
 
==External Links==
*[https://www.cdc.gov/fungal/diseases/histoplasmosis/index.html CDC: Histoplasmosis]
 
==References==
<references/>
<references/>
[[Category:ID]]
[[Category:ID]]

Latest revision as of 03:48, 8 March 2021

Background

  • Fungal infection caused by Histoplasma capsulatum[1]
  • Endemic to the Ohio, Missouri, and Mississippi River valleys in the United States[2]
  • Exposure from disruption of soil containing organisms leads to aerosolization[3]
  • Activities associated with high-level exposure include spelunking, excavation, and demolition of old buildings
Histoplasmosis after return from Pennsylvania, United States

Pathogenesis

  • Infection occurs via inhalation[4]
  • In immunocompetent patients:
    • Phagocytes and epithelial cells eventually organize and form granulomas that go on to fibrose and calcify
  • In immunocompromised patients:
    • The infection is not contained and can disseminate

Clinical Features

Disease manifestation depends on intensity of exposure, immune status, and underlying lung architecture

Acute Pulmonary Histoplasmosis

  • 90% asymptomatic, and usually self-limited
  • Symptoms 1-4 weeks after exposure and consist of flu-like illness[5]
    • Fever/chills
    • Headache
    • Malaise
    • Myalgias
    • Abdominal pain
    • Arthralgias
    • Dyspnea
    • Cough, hemoptysis
  • Hilar/mediastinal lymphadenopathy on CXR

Chronic Pulmonary Histoplasmosis

  • Mostly older patients or smokers with underlying structural lung disease[6]
  • Symptoms:
    • Cough
    • Weight loss
    • Low-grade fever
    • Malaise
    • Night sweats
    • Sometimes hemoptysis, sputum production, dyspnea
  • CXR may show:
    • Upper lobe infiltrates
    • Fibrosis, scarring
    • Cavitations

Progressive Disseminated Histoplasmosis

  • Seen in immunocompromised patients
  • SIRS
  • Acute form:
    • Diffuse interstitial or reticulonodular lung infiltrates
    • Respiratory failure
    • Coagulopathy
    • Multiorgan failure
  • Subacute form depends on focal organ system affected:
    • Fever
    • Weight loss
    • Hepatosplenomegaly
    • Meningitis, brain lesions
    • Mucosal or GI ulcerations
    • Adrenal insufficiency
    • Pericarditis
  • Chronic form: constitutional sx

Mediastinitis

  • Enlarged lymph nodes that may undergo necrosis
  • This leads to granulomatous mediastinitis
  • Can lead to:
    • Superior vena cava syndrome
    • Obstruction of pulmonary vessels
    • Airway obstruction
    • Recurrent pneumonia
    • Hemoptysis
    • Respiratory failure

Differential Diagnosis

Causes of Pneumonia

Bacteria

Viral

Fungal

Parasitic

Evaluation

Workup

  • CXR
    • Normal in 40-70% of cases
    • Pneumonitis with hilar adenopathy
    • Focal pulmonary infiltrates with light exposure
    • Diffuse infiltrates with heavy exposure
  • CBC - mild anemia in chronic disease
  • Liver panel - alkaline phosphatase elevated in disseminated and chronic disease
  • LDH - elevated in AIDS patients with disseminated disease
  • Definitive diagnosis by:
    • Sputum cultures
    • Blood cultures
    • Antibody testing
    • Serum/urine antigen testing
  • Further imaging if concerned for specific organ involvement in disseminated disease (Head CT, Abdominal CT or Lumbar puncture)

Management

Acute Pulmonary Histoplasmosis

  • Do not treat if asymptomatic
    • Not progressive, resolves without treatment, only rarely reactivates

Progressive Disseminated Histoplasmosis

  • Pulmonary cases: Itraconazole x 6-12 weeks[7]
  • Severe disease: Amphotericin B x 1 week then Itraconazole x 1 year[8]
  • Surgical intervention may be necessary in some cases

Chronic Pulmonary Histoplasmosis

Disposition

  • Discharge asymptomatic cases
  • Discharge mildly symptomatic immunocompetent patients with primary care follow up
  • Admit severe symptoms or symptomatic immunocompromised patients

See Also

External Links

References

  1. ↑ Lowell JR. Diagnosis of histoplasmosis. Ann Intern Med. Feb 1983;98(2):260
  2. ↑ Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008. MMWR Morb Mortal Wkly Rep. Dec 19 2008;57(50):1349-53
  3. ↑ Hage, Chadi A., and L. Joseph Wheat. "Chapter 199. Histoplasmosis." Harrison's Principles of Internal Medicine, 18e. Eds. Dan L. Longo, et al. New York, NY: McGraw-Hill, 2012. n. pag. AccessMedicine. Web. 4 Dec. 2014
  4. ↑ “Histoplasmosis.” CDC. (2014, Sept. 25) Web 4 Dec. 2014. http://www.cdc.gov/fungal/diseases/histoplasmosis
  5. ↑ http://www.ncbi.nlm.nih.gov/pubmed/24528944
  6. ↑ http://www.ncbi.nlm.nih.gov/pubmed/23664715
  7. ↑ Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807-825
  8. ↑ Hospenthal DR, Becker SJ. Update on Therapy for Histoplasmosis. Infect Med. April 13 2009;26:121-124
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