Ivermectin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Strongyloidiasis]]=== | |||
*0.2mg/kg PO x1 | |||
===[[Onchocerciasis]]=== | |||
*0.15mg/kg PO x1 | |||
===[[Scabies]], non-crusted=== | |||
*0.2mg/kg PO x1 | |||
===[[Scabies]], crusted=== | |||
*0.2mg/kg PO x1 on days 1,2,8,9,15 | |||
===[[Pediculosis capitis]]=== | |||
*0.2mg/kg pO q10 days x2 doses | |||
===[[Pediculosis corporis]]=== | |||
*12mg PO q7 days x3 doses | |||
===[[Pediculosis pubis]]=== | |||
*0.25mg/kg PO q2wk x2 doses | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Adult]] | {{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Adult]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Pediatric]] | {{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Pediatric]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
Revision as of 02:39, 20 March 2026
General
- Type: antiparasitic
- Dosage Forms: Tablet, 3mg
- Common Trade Names: Stromectol
Adult Dosing
Strongyloidiasis
- 0.2mg/kg PO x1
Onchocerciasis
- 0.15mg/kg PO x1
Scabies, non-crusted
- 0.2mg/kg PO x1
Scabies, crusted
- 0.2mg/kg PO x1 on days 1,2,8,9,15
Pediculosis capitis
- 0.2mg/kg pO q10 days x2 doses
Pediculosis corporis
- 12mg PO q7 days x3 doses
Pediculosis pubis
- 0.25mg/kg PO q2wk x2 doses
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Onchocerciasis | 0.15mg/kg PO x1 | Onchocerciasis |
| Scabies | 200mcg/kg PO repeat in 2wks | Severe infection |
| Strongyloides stercoralis | 0.2mg/kg PO x1 | Strongyloidiasis |
Pediatric Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Scabies | 200mcg/kg PO, repeat in 2 weeks; only for children >15kg | Pediatric Severe (>15kg) |
Special Populations
- Pregnancy Rating: C
- Lactation: Safety Unknown
- Renal Dosing- not defined
- Hepatic Dosing- not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- hypotension, orthostatic
- tachycardia
- seizures
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- asthma exacerbation
- vision loss
- conjunctival hemorrhage
- hepatitis
Common
- pruritus
- rash
- fever
- edema
- lymphadenopathy
- headache
- myalgia
- dizziness
- tachycardia
- abnormal eye sensation
- limbitis
- conjunctivitis
- ocular inflammation
- hypotension, orthostatic
- ALT, AST elevated
- eosinophilia
Pharmacology
- Half-life: 18h
- Metabolism: liver, CYP450: unknown
- Excretion: feces primarily, urine < 1%
- Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite