Cor pulmonale

Background

• Remodeling of right ventricle in response to pulmonary pathology
• Often caused by COPD, pulmonary hypertension, PE, ARDS

Clinical Features

Pathophysiology

• Pulmonary vasoconstriction (hypoxia, acidemia)
• Destruction of pulmonary vasculature by emphysema, ILD
• Increased blood viscosity (sickle cell disease, polycythemia)

Chronic

• RVH

Acute

• RV dilation

Signs and Symptoms

• Cough
• Dyspnea
• Tachypnea
• Hemoptysis
• Syncope
• Peripheral edema
• Cyanosis

Diagnosis

Blood tests

• CBC (polycythemia)
• ABG (oxygenation, acid-base status)
• alpha-1-antitrypsin
• ANA
• Coagulation studies (protein C/S, factor V Leiden etc)

CXR

• Enlarged pulmonary arteries
• Cardiomegaly
• Decreased retrosternal air space

EKG

• RVH
• Right axis deviation
• Right bundle branch block
• R:S ratio > 1 in V1
• Large P wave in II, III, aVF
• Arrhythmia (PAC, SVT, MFAT, A-fib, A-flutter)

Echo

• Increased RV thickness
• RV dilation
• Tricuspid insufficiency
• High estimated PA pressures
• Septal bowing into LV