Flunisolide

Administration

  • Type: Inhaled corticosteroid
  • Dosage Forms: 80mcg/spray
  • Routes of Administration: Inhalation
  • Common Trade Names: Aerospan

Adult Dosing

  • Inhalation: 2-4 puffs BID
    • Max: 640 mcg/day

Pediatric Dosing

  • 6-11 yo: 1-2 puffs BID
    • Max: 320 mcg/day
  • >12 yo: 2-4 puffs BID
    • Max: 640 mcg/day

Special Populations

Renal Dosing

  • Adult: Not Defined
  • Pediatric: Not Defined

Hepatic Dosing

  • Adult: Not Defined
  • Pediatric: Not Defined

Contraindications

  • Allergy to class/drug
  • Hypersensitivity to drug/class
  • Status asthmaticus
  • Asthma, acute
  • Avoid abrupt withdrawal
  • Bronchospasm, acute

Adverse Reactions

Serious

  • Bronchospasm
  • Adrenal suppression
  • Hypercorticism
  • Growth suppression (peds pts)
  • Glaucoma
  • Cataracts
  • Osteoporosis
  • erythema multiforme

Common

Pharmacology

  • Half-life: 1.3-1.7 hr
  • Metabolism: Liver; CYP450: 3A4 substrate
  • Excretion: Urine <1%

Mechanism of Action

Exact mechanism unknown. Inhibits multiple inflammatory cytokines and produces multiple glucocorticoid and mineralocorticoid effects.

See Also

Corticosteroids

References