Hydrocortisone topical
(Redirected from Hydrocortisone)
General
- Type: Topical steroid
- Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
- Common Trade Names: Cortizone, Cortaid, Hytone, Texacort
Adult Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Pediatric Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Special Populations
- Pregnancy Rating: C
- Lactation: Excretion in milk unknown; use with caution
- Renal Dosing: None
- Hepatic Dosing: None
Contraindications
- Allergy to class/drug
- caution if skin infection
- caution in pediatric patients
Adverse Reactions
Serious
- HPA axis suppresion
- Cushing syndrome
- hyperglycemia
- intracranial hypertension (pediatric patients)
Common
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Pharmacology
- Half-life: 8-12h
- Metabolism: liver primarily; CYP450
- Excretion: urine
- Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| COPD exacerbation | 100-125 mg IV q6h x5 days | Corticosteroid (IV option) | IV | Adult |
| Pituitary apoplexy | 100-200mg IV bolus, then 2-4mg/hr infusion | Stress-dose corticosteroid replacement | IV | Adult |
| Sepsis (main) | 50 mg IV q6h (200 mg/day) | Stress dose steroids for septic shock | IV | Adult |
| Thyroid storm | 300 mg IV bolus, then 100 mg IV TID | Adrenal insufficiency treatment + T4→T3 blockade | IV | Adult |
| Toxic megacolon | 100mg q6hr | Anti-inflammatory for underlying IBD | IV | Adult |