Lorazepam

General

  • Type: Benzodiazepine
  • Dosage Forms: Tablet: 0.5, 1, 2 mg. IV solution: 2mg/ml, 4 mg/ml
  • Common Trade Names: Ativan

Adult Dosing

Pediatric Dosing

Seizure

  • 0.1 mg/kg IV

Special Populations

  • Pregnancy Rating:
  • Lactation:
    • Lorazepam is present in breast milk
  • Renal Dosing
    • Adult
      • PO: no adjustment necessary
      • IV:
        • Mild to moderate impairment
          • No adjustment necessary
        • Severe impairment
          • Use not recommended
    • Pediatric
      • PO: not defined
      • IV:
        • Mild to moderate impairment
          • No adjustment necessary
        • Severe impairment
          • Use not recommended
  • Hepatic Dosing
    • Adult
      • PO:
        • Mild to moderate impairment: No adjustment necessary
        • Severe impairment: May need lower doses, use caution
      • IV:
        • Mild to moderate impairment: No adjustment necessary
        • Severe impairment: Use not recommended
    • Pediatric
      • ≥ 12 years old: No adjustment necessary however use caution with severe hepatic disease

Contraindications

  • Allergy to class/drug
  • respiratory depression

Adverse Reactions

Serious

  • Respiratory depression
  • apnea
  • hypotension
  • paradoxical CNS stimulation

Common

  • sedation
  • ataxia
  • disinhibition
  • dysarthria

Pharmacology

  • Half-life: 10-20 hours
  • Metabolism: liver
  • Excretion: renal
  • Mechanism of Action: GABA receptor agonist

See Also

References

  • Lorazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.