Myelofibrosis

Background

Clinical Features

  • Palpable splenomegaly
  • Bone pain

Differential Diagnosis

Evaluation

Workup

  • CBC
  • Blood smear
  • Chem 7
  • Bone marrow biopsy

Diagnosis[1]

  • Criteria: The diagnosis of primary myelofibrosis requires meeting all 3 major criteria and 2 minor criteria.
Major criteria
Megakaryocyte proliferation and atypia with reticulin and/or collagen fibrosis,

or with increased marrow cellularity, granulocytic proliferation, and decreased erythropoiesis

Not meeting WHO criteria for CML, PV, MDS, or other myeloid neoplasm
Demonstration of JAK2V617F or other clonal marker or no evidence of reactive bone marrow fibrosis
Minor criteria
Leukoerythroblastosis
Increased serum LDH
Anemia
Palpable splenomegaly

Management

Also See

References

  1. Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,