Obiltoxaximab

Administration

  • Type: Monoclonal Antibody
  • Dosage Forms: IV
  • Routes of Administration: IV
  • Common Trade Names: Anthim
  • Info: Distributed directly to CDC

Adult Dosing

Inhalation anthrax treatment

Inhalation anthrax prophylaxis, post-exposure

  • <40 kg
  • >40 kg

Pediatric Dosing

Inhalation anthrax treatment

Inhalation anthrax prophylaxis, post-exposure

  • <15 kg
  • 16-40 kg
  • >40 kg

Special Populations

  • Pregnancy Rating: C; Benefits outweigh risks during pregnancy.
  • Lactation risk: L3; Safety unknown

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 15-23 Days
  • Metabolism: Other; CYP450: unknown
  • Excretion: Other

Mechanism of Action

  • A monoclonal antibody that binds to anthrax toxin to prevent lethal and edema factors' intracellular entry and neutralizes toxic effects.

Comments

See Also

References