Vitamin K deficiency

Background

  • Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
    • Used by liver
    • Fat soluble

Causes

  • Nutritional deficiency
  • Malabsorption
  • Cholestasis: since it is fat soluble and needs bile salts to be absorbed

Clinical Features

  • Increased bleeding

Differential Diagnosis

Coagulopathy

Platelet Related

Factor Related

Vitamin deficiencies

Management

  • Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
  • Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off

Disposition

See Also

References