Granulomatosis with polyangiitis

(Redirected from Wegener's granulomatosis)

Background

  • Formerly known as Wegener's granulomatosis
  • c-ANCA associated systemic necrotizing vasculitis
  • Small- and medium-sized blood vessels
  • Predilection for upper and lower respiratory tracts and kidneys

Vasculitis Syndrome Types

Clinical Features

Differential Diagnosis

Evaluation

Bilateral upper lobe nodular lesions in a patient with Granulomatosis with polyangiitis presenting with hemoptysis.

Workup

Classification

  • American College of Rheumatology: 88% sensitivity and 92% specificity for ≥2 criteria
  • Nasal or oral inflammation
  • Abnormal chest radiograph showing nodules, fixed infiltrate, or cavities
  • Abnormal urinary sedimentation (microscopic hematuria)
  • Granulomatous inflammation on biopsy of an artery or perivascular area

Management

Disposition

See Also

References