Traveler's diarrhea: Difference between revisions
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==Background==
==Background==
*A diarrheal syndrome which may be caused by a variety of intestinal pathogens contracted while traveling, particularly in low-income countries
*A diarrheal syndrome which may be caused by a variety of intestinal pathogens contracted while traveling, particularly in low-income countries
Bacteria account for a majority of cases, but traveler's diarrhea may also be caused by parasites or viruses.
Bacteria account for a majority of cases, but traveler's diarrhea may also be caused by parasites or viruses.
**Is the most common [[travel-associated disease]]
**Is the most common [[Special:MyLanguage/travel-associated disease|travel-associated disease]]
**Greatest contributor to illness poor hygiene in restaurants <ref> http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/travelers-diarrhea</ref>
**Greatest contributor to illness poor hygiene in restaurants <ref> http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/travelers-diarrhea</ref>
*Most cases of traveler’s diarrhea are caused by bacterial enteropathogens, whereas bacterial pathogens cause less than 15% of endemic diarrhea cases in adults living in their home country<ref name="Steffen">Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006</ref>
*Most cases of traveler’s diarrhea are caused by bacterial enteropathogens, whereas bacterial pathogens cause less than 15% of endemic diarrhea cases in adults living in their home country<ref name="Steffen">Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006</ref>
**Most cases respond to antibiotics (as opposed to non-traveler's [[acute gastroenteritis]], which is most commonly caused by viruses)
**Most cases respond to antibiotics (as opposed to non-traveler's [[Special:MyLanguage/acute gastroenteritis|acute gastroenteritis]], which is most commonly caused by viruses)
**As duration of diarrhea increases, higher chance of parasitic cause
**As duration of diarrhea increases, higher chance of parasitic cause
*At risk populations- Immunosuppressed, diabetes, taking meds to suppress acid production
*At risk populations- Immunosuppressed, diabetes, taking meds to suppress acid production


===Etiology<ref name="Steffen"></ref>===
===Etiology<ref name="Steffen"></ref>===
{| class="wikitable"
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
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| align="center" style="background:#f0f0f0;"|'''Southeast Asia'''
| align="center" style="background:#f0f0f0;"|'''Southeast Asia'''
|-
|-
| Enterotoxigenic [[Escherichia coli]]|| ≥35|| 25-35 ||15-25|| 5-15
| Enterotoxigenic [[Special:MyLanguage/Escherichia coli|Escherichia coli]]|| ≥35|| 25-35 ||15-25|| 5-15
|-
|-
| Enteroaggregative [[E coli]] ||25-35 ||<5 ||15-25 ||No data
| Enteroaggregative [[Special:MyLanguage/E coli|E coli]] ||25-35 ||<5 ||15-25 ||No data
|-
|-
| [[Campylobacter]] ||<5 ||<5 ||15-25 ||25-35
| [[Special:MyLanguage/Campylobacter|Campylobacter]] ||<5 ||<5 ||15-25 ||25-35
|-
|-
| [[Salmonella]]|| <5 ||5-15 ||<5|| 5-15
| [[Special:MyLanguage/Salmonella|Salmonella]]|| <5 ||5-15 ||<5|| 5-15
|-
|-
| [[Shigella]]||5-15 ||5-15|| 5-15 ||<5
| [[Special:MyLanguage/Shigella|Shigella]]||5-15 ||5-15|| 5-15 ||<5
|-
|-
| [[Norovirus]] ||15-25||15-25 ||5-15 ||<5
| [[Special:MyLanguage/Norovirus|Norovirus]] ||15-25||15-25 ||5-15 ||<5
|-
|-
| [[Rotavirus]] ||15-25 ||5-15||5-15 ||<5
| [[Special:MyLanguage/Rotavirus|Rotavirus]] ||15-25 ||5-15||5-15 ||<5
|-
|-
| [[Giardia]] ||<5 ||<5 ||5-15 ||5-15
| [[Special:MyLanguage/Giardia|Giardia]] ||<5 ||<5 ||5-15 ||5-15
|}
|}


==Clinical Features==
==Clinical Features==
Characterized by the following:<ref name="Steffen"></ref>
Characterized by the following:<ref name="Steffen"></ref>
*Travel
*Travel
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**Abdominal cramps
**Abdominal cramps
**Tenesmus
**Tenesmus
**[[Nausea]]
**[[Special:MyLanguage/Nausea|Nausea]]
**[[Vomiting]]
**[[Special:MyLanguage/Vomiting|Vomiting]]
**[[Fever]]
**[[Special:MyLanguage/Fever|Fever]]
**Fecal urgency
**Fecal urgency


;The average duration of untreated traveler’s diarrhea is 4 to 5 days<ref name="Steffen"></ref>
;The average duration of untreated traveler’s diarrhea is 4 to 5 days<ref name="Steffen"></ref>


==Differential Diagnosis==
==Differential Diagnosis==
</translate>
{{Diarrhea DDX}}
{{Diarrhea DDX}}
<translate>


==Evaluation==
==Evaluation==
''Diagnosis is typically made clinically''
''Diagnosis is typically made clinically''
===Uncomplicated Diarrhea===
===Uncomplicated Diarrhea===
*No workup<ref name="Steffen"></ref>
*No workup<ref name="Steffen"></ref>


===Fever, Bloody Stools, or Ill Appearing===
===Fever, Bloody Stools, or Ill Appearing===
*Stool culture <ref name="Steffen"></ref>
*Stool culture <ref name="Steffen"></ref>
*Systemic toxicity
*Systemic toxicity
**Extended workup including blood cultures
**Extended workup including blood cultures


===Persistent or Refractory Diarrhea (>14 days)===
===Persistent or Refractory Diarrhea (>14 days)===
*Typically not done in the ER (at follow-up)
*Typically not done in the ER (at follow-up)
**Stool culture (including [[Salmonella]], [[Shigella]], and [[Campylobacter]])
**Stool culture (including [[Special:MyLanguage/Salmonella|Salmonella]], [[Special:MyLanguage/Shigella|Shigella]], and [[Special:MyLanguage/Campylobacter|Campylobacter]])
**Stool O&P (including testing for protozoal parasites, [[Giardia]], [[Cryptosporidium]])<ref name="Steffen"></ref>
**Stool O&P (including testing for protozoal parasites, [[Special:MyLanguage/Giardia|Giardia]], [[Special:MyLanguage/Cryptosporidium|Cryptosporidium]])<ref name="Steffen"></ref>
**Fecal leukocytes, giardia antigen, C. difficile PCR
**Fecal leukocytes, giardia antigen, C. difficile PCR


==Management==
==Management==
===Supportive Care===
===Supportive Care===
*PO hydration and consider [[oral rehydration fluids]]
 
*Consider [[ondansetron]] if concurrent nausea/vomiting
*PO hydration and consider [[Special:MyLanguage/oral rehydration fluids|oral rehydration fluids]]
*[[Bismuth subsalicylate]] (Pepto Bismol) ~524 mg every 30 to 60 minutes or 1,050 mg every 60 minutes as needed (maximum: ~4,200 mg/24 hours)<ref>Brum, et al. Systematic Review and Meta-Analyses Assessment of the Clinical Efficacy of Bismuth Subsalicylate for Prevention and Treatment of Infectious Diarrhea. Dig Dis Sci. 2021; 66(7): 2323–2335. doi: 10.1007/s10620-020-06509-7</ref>  
*Consider [[Special:MyLanguage/ondansetron|ondansetron]] if concurrent nausea/vomiting
*Consider [[IVF]] if dehydrated
*[[Special:MyLanguage/Bismuth subsalicylate|Bismuth subsalicylate]] (Pepto Bismol) ~524 mg every 30 to 60 minutes or 1,050 mg every 60 minutes as needed (maximum: ~4,200 mg/24 hours)<ref>Brum, et al. Systematic Review and Meta-Analyses Assessment of the Clinical Efficacy of Bismuth Subsalicylate for Prevention and Treatment of Infectious Diarrhea. Dig Dis Sci. 2021; 66(7): 2323–2335. doi: 10.1007/s10620-020-06509-7</ref>  
*Consider [[loperamide]] 4mg PO followed by 2mg after each loose stool (Max: 16mg/day)<ref name="Steffen"></ref>
*Consider [[Special:MyLanguage/IVF|IVF]] if dehydrated
*Consider [[Special:MyLanguage/loperamide|loperamide]] 4mg PO followed by 2mg after each loose stool (Max: 16mg/day)<ref name="Steffen"></ref>
**If very frequent stools and no contra-indication:
**If very frequent stools and no contra-indication:
***Not pregnant
***Not pregnant
***>2 years old
***>2 years old
***[[Fever]] or bloody stools without concomitant antibiotics (do not use as sole therapy)
***[[Special:MyLanguage/Fever|Fever]] or bloody stools without concomitant antibiotics (do not use as sole therapy)


===[[Antibiotics]]<ref name="Steffen"></ref>===
 
===[[Special:MyLanguage/Antibiotics|Antibiotics]]<ref name="Steffen"></ref>===
 
</translate>
{{Travelers Diarrhea Antibiotics}}
{{Travelers Diarrhea Antibiotics}}
<translate>


===Pediatrics===
===Pediatrics===
'''Antibiotic Options:'''
'''Antibiotic Options:'''
</translate>
{{Travelers Diarrhea Pediatric Antibiotics}}
{{Travelers Diarrhea Pediatric Antibiotics}}
<translate>


==Disposition==
==Disposition==
*Outpatient for the vast majority
*Outpatient for the vast majority
*Consider admission if systemic toxicity
*Consider admission if systemic toxicity


==Complications==
==Complications==
*[[Postinfectious irritable bowel syndrome]]
 
*[[Reactive arthritis]]
*[[Special:MyLanguage/Postinfectious irritable bowel syndrome|Postinfectious irritable bowel syndrome]]
*[[Guillain-Barre syndrome]]
*[[Special:MyLanguage/Reactive arthritis|Reactive arthritis]]
*[[Special:MyLanguage/Guillain-Barre syndrome|Guillain-Barre syndrome]]
 


==See Also==
==See Also==
*[[Diarrhea]]
 
*[[Diarrhea (Peds)]]
*[[Special:MyLanguage/Diarrhea|Diarrhea]]
*[[Travel Medicine]]
*[[Special:MyLanguage/Diarrhea (Peds)|Diarrhea (Peds)]]
*[[Special:MyLanguage/Travel Medicine|Travel Medicine]]
 


==External Links==
==External Links==
*[http://wwwnc.cdc.gov/travel/page/travelers-diarrhea CDC - Travelers Diarrhea]
*[http://wwwnc.cdc.gov/travel/page/travelers-diarrhea CDC - Travelers Diarrhea]


==References==
==References==
<references/>  
<references/>  


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[[Category:ID]]
[[Category:ID]]
[[Category:Tropical Medicine]]
[[Category:Tropical Medicine]]




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==References==
==References==
<references/>
<references/>
</translate>

Latest revision as of 00:01, 5 January 2026


Background

  • A diarrheal syndrome which may be caused by a variety of intestinal pathogens contracted while traveling, particularly in low-income countries

Bacteria account for a majority of cases, but traveler's diarrhea may also be caused by parasites or viruses.

  • Most cases of traveler’s diarrhea are caused by bacterial enteropathogens, whereas bacterial pathogens cause less than 15% of endemic diarrhea cases in adults living in their home country[2]
    • Most cases respond to antibiotics (as opposed to non-traveler's acute gastroenteritis, which is most commonly caused by viruses)
    • As duration of diarrhea increases, higher chance of parasitic cause
  • At risk populations- Immunosuppressed, diabetes, taking meds to suppress acid production


Etiology[2]

Organism Latin America and Caribbean Africa South Asia Southeast Asia
Enterotoxigenic Escherichia coli ≥35 25-35 15-25 5-15
Enteroaggregative E coli 25-35 <5 15-25 No data
Campylobacter <5 <5 15-25 25-35
Salmonella <5 5-15 <5 5-15
Shigella 5-15 5-15 5-15 <5
Norovirus 15-25 15-25 5-15 <5
Rotavirus 15-25 5-15 5-15 <5
Giardia <5 <5 5-15 5-15


Clinical Features

Characterized by the following:[2]

  • Travel
  • 3 or more unformed stools per 24 hours
  • Plus (at least 1 of the following):
The average duration of untreated traveler’s diarrhea is 4 to 5 days[2]


Differential Diagnosis

Acute diarrhea

Infectious

Noninfectious

Watery Diarrhea

Traveler's Diarrhea


Evaluation

Diagnosis is typically made clinically

Uncomplicated Diarrhea


Fever, Bloody Stools, or Ill Appearing

  • Stool culture [2]
  • Systemic toxicity
    • Extended workup including blood cultures


Persistent or Refractory Diarrhea (>14 days)


Management

Supportive Care

  • PO hydration and consider oral rehydration fluids
  • Consider ondansetron if concurrent nausea/vomiting
  • Bismuth subsalicylate (Pepto Bismol) ~524 mg every 30 to 60 minutes or 1,050 mg every 60 minutes as needed (maximum: ~4,200 mg/24 hours)[4]
  • Consider IVF if dehydrated
  • Consider loperamide 4mg PO followed by 2mg after each loose stool (Max: 16mg/day)[2]
    • If very frequent stools and no contra-indication:
      • Not pregnant
      • >2 years old
      • Fever or bloody stools without concomitant antibiotics (do not use as sole therapy)


Antibiotics[2]


Pediatrics

Antibiotic Options:

Avoid fluroquinolones


Disposition

  • Outpatient for the vast majority
  • Consider admission if systemic toxicity


Complications


See Also


External Links


References

  1. ↑ http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/travelers-diarrhea
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  3. ↑ Marx et al. “Cholera and Gastroenteritis caused by Noncholera Vibrio Species”. Rosen’s Emergency Medicine 8th edition vol 1 pg 1245-1246.
  4. ↑ Brum, et al. Systematic Review and Meta-Analyses Assessment of the Clinical Efficacy of Bismuth Subsalicylate for Prevention and Treatment of Infectious Diarrhea. Dig Dis Sci. 2021; 66(7): 2323–2335. doi: 10.1007/s10620-020-06509-7
  5. ↑ Hoge CW. et al. Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis. 1998;26:341–5
  6. ↑ Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  7. ↑ Sanders JW. et al. An observational clinic-based study of diarrheal illness in deployed United States military personnel in Thailand: presentation and outcome of Campylobacter infection. Am J Trop Med Hyg. 2002;67:533–8
  8. ↑ Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  9. ↑ Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  10. ↑ DuPont HL. et al. Rifaximin versus ciprofloxacin for the treatment of traveler’s diarrhea: a randomized, double-blind clinical trial. Clin Infect Dis. 2001;33:1807–15
  11. ↑ Stauffer WM, Konop RJ, Kamat D. Traveling with infants and young children. Part III: travelers’ diarrhea. J Travel Med. 2002;9:141–50


See Also

External Links

References

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