| | Drug | Dose | Indication | Context | Population | Route |
|---|
| Acute allergic reaction#Methylprednisolone Corticosteroid Adult | Methylprednisolone | 125mg | Acute allergic reaction | Corticosteroid | Adult | IV/IM |
| Acute allergic reaction#Prednisone Corticosteroid (outpatient) Adult | Prednisone | 60mg initially, then 40mg PO daily x 5 days | Acute allergic reaction | Corticosteroid (outpatient) | Adult | PO |
| Acute allergic reaction#Diphenhydramine H1 antagonist Adult | Diphenhydramine | 50mg | Acute allergic reaction | H1 antagonist | Adult | IV/IM/PO |
| Acute allergic reaction#Cetirizine H1 antagonist; less sedating alternative Adult | Cetirizine | 10mg | Acute allergic reaction | H1 antagonist; less sedating alternative | Adult | IV/PO |
| Acute allergic reaction#Cetirizine H1 antagonist; less sedating alternative Pediatric | Cetirizine | 5-10mg IV (6-11yo); 2.5mg IV (6mo-5yo) | Acute allergic reaction | H1 antagonist; less sedating alternative | Pediatric | IV |
| Acute allergic reaction#Famotidine H2 antagonist; improves urticaria Adult | Famotidine | 40mg | Acute allergic reaction | H2 antagonist; improves urticaria | Adult | IV/IM/PO |
| Acute arterial ischemia#Unfractionated heparin Anticoagulation to prevent clot propagation Adult | Unfractionated heparin | 80 units/kg bolus, then 18 units/kg/hr infusion | Acute arterial ischemia | Anticoagulation to prevent clot propagation | Adult | IV |
| Acute asthma exacerbation#Magnesium sulfate Adjunct for moderate-severe asthma Adult | Magnesium sulfate | 25-75 mg/kg IV over 30 min (2-3 g in most adults) | Acute asthma exacerbation | Adjunct for moderate-severe asthma | Adult | IV |
| Acute asthma exacerbation#Ipratropium Anticholinergic adjunct (acute setting only) Adult | Ipratropium | 0.25-0.5 mg nebulized q20min x2-3 doses | Acute asthma exacerbation | Anticholinergic adjunct (acute setting only) | Adult | Nebulized |
| Acute asthma exacerbation#Terbutaline Beta-2 agonist (longer-acting) Adult | Terbutaline | 0.25 mg SC/IM q20min x3 | Acute asthma exacerbation | Beta-2 agonist (longer-acting) | Adult | SC/IM |
| Acute asthma exacerbation#Albuterol Bronchodilator (1st line) Adult | Albuterol | 2.5-5 mg nebulized q20min x3, then 2.5-10 mg q1-4hr PRN; or continuous 0.5 mg/kg/hr (max 15 mg/hr) | Acute asthma exacerbation | Bronchodilator (1st line) | Adult | Nebulized |
| Acute asthma exacerbation#Albuterol Bronchodilator (MDI alternative) Adult | Albuterol | 6-12 puffs MDI q20min up to 4h, then q1-4hr PRN | Acute asthma exacerbation | Bronchodilator (MDI alternative) | Adult | MDI |
| Acute asthma exacerbation#Albuterol Bronchodilator (pediatric) Pediatric | Albuterol | 0.15 mg/kg (min 2.5 mg) nebulized q20min x3, then 0.15-0.3 mg/kg q1-4h PRN; or continuous 0.5 mg/kg/hr | Acute asthma exacerbation | Bronchodilator (pediatric) | Pediatric | Nebulized |
| Acute asthma exacerbation#Prednisone Corticosteroid Adult | Prednisone | 40-60 mg PO daily x5 days | Acute asthma exacerbation | Corticosteroid | Adult | PO |
| Acute asthma exacerbation#Methylprednisolone Corticosteroid (if unable to tolerate PO) Adult | Methylprednisolone | 1 mg/kg IV q4-6h | Acute asthma exacerbation | Corticosteroid (if unable to tolerate PO) | Adult | IV |
| Acute asthma exacerbation#Prednisone Corticosteroid (pediatric) Pediatric | Prednisone | 1-2 mg/kg/day (max 60 mg) x3-10 days | Acute asthma exacerbation | Corticosteroid (pediatric) | Pediatric | PO |
| Acute asthma exacerbation#Dexamethasone Corticosteroid (preferred for adherence) Adult | Dexamethasone | 0.6 mg/kg IV or PO (max 16 mg); 2nd dose 24hr later | Acute asthma exacerbation | Corticosteroid (preferred for adherence) | Adult | IV/PO |
| Acute asthma exacerbation#Magnesium sulfate High-dose magnesium (pediatric) Pediatric | Magnesium sulfate | 50 mg/kg/hr IV x4 hours (max 8000 mg total) | Acute asthma exacerbation | High-dose magnesium (pediatric) | Pediatric | IV drip |
| Acute asthma exacerbation#Ketamine Induction for intubation / bronchodilator adjunct Adult | Ketamine | 1-2 mg/kg IV (induction); 1 mg/kg/hr drip (sedation) | Acute asthma exacerbation | Induction for intubation / bronchodilator adjunct | Adult | IV |
| Acute asthma exacerbation#Epinephrine Severe/life-threatening asthma Adult | Epinephrine | 0.01 mg/kg (1:1000) SC or IM q20min x3 (max 0.5 mg) | Acute asthma exacerbation | Severe/life-threatening asthma | Adult | SC/IM |
| Acute asthma exacerbation (peds)#Ipratropium Adjunctive anticholinergic; reduces admissions Pediatric | Ipratropium | 0.25-0.5mg q20min x3 (with first 3 albuterol doses) | Acute asthma exacerbation (peds) | Adjunctive anticholinergic; reduces admissions | Pediatric | Nebulized |
| Acute asthma exacerbation (peds)#Albuterol First-line bronchodilator Pediatric | Albuterol | 2.5-5mg nebulized q20min x3 (intermittent) or 0.5mg/kg/hr continuous (max 15mg/hr) | Acute asthma exacerbation (peds) | First-line bronchodilator | Pediatric | Nebulized |
| Acute asthma exacerbation (peds)#Magnesium sulfate Severe/refractory asthma; smooth muscle relaxation Pediatric | Magnesium sulfate | 25-50mg/kg (max 2g) IV over 20min | Acute asthma exacerbation (peds) | Severe/refractory asthma; smooth muscle relaxation | Pediatric | IV |
| Acute asthma exacerbation (peds)#Prednisone Systemic corticosteroid alternative to dexamethasone Pediatric | Prednisone | 1-2mg/kg/day (max 60mg) in 1-2 divided doses x 3-5 days | Acute asthma exacerbation (peds) | Systemic corticosteroid alternative to dexamethasone | Pediatric | PO |
| Acute asthma exacerbation (peds)#Dexamethasone Systemic corticosteroid; PO and IV equally effective Pediatric | Dexamethasone | 0.6mg/kg PO or IV (max 16mg); consider 2nd dose at 24-36hr | Acute asthma exacerbation (peds) | Systemic corticosteroid; PO and IV equally effective | Pediatric | PO/IV |
| Acute mountain sickness#Acetazolamide Mild AMS; speeds acclimatization via bicarb diuresis Adult | Acetazolamide | 125-250mg BID | Acute mountain sickness | Mild AMS; speeds acclimatization via bicarb diuresis | Adult | PO |
| Acute mountain sickness#Acetazolamide Moderate-severe AMS Adult | Acetazolamide | 250mg BID | Acute mountain sickness | Moderate-severe AMS | Adult | PO |
| Acute mountain sickness#Dexamethasone Moderate-severe AMS; symptomatic relief only, does not aid acclimatization Adult | Dexamethasone | 4mg q6hr | Acute mountain sickness | Moderate-severe AMS; symptomatic relief only, does not aid acclimatization | Adult | PO |
| Acute pain management#Gabapentin Neuropathic pain adjuvant Adult | Gabapentin | 300 mg PO qhs (starting dose) | Acute pain management | Neuropathic pain adjuvant | Adult | PO |
| Acute pain management#Indomethacin Non-opioid analgesic (NSAID) Adult | Indomethacin | 25-50 mg PO q12h or 100 mg PR q24h | Acute pain management | Non-opioid analgesic (NSAID) | Adult | PO/PR |
| Acute pain management#Naproxen Non-opioid analgesic (NSAID) Adult | Naproxen | 250 mg PO q6-8h or 500-1000 mg PR q6-8h | Acute pain management | Non-opioid analgesic (NSAID) | Adult | PO/PR |
| Acute pain management#Ketorolac Non-opioid analgesic (NSAID, parenteral) Adult | Ketorolac | 15-30 mg IV q6h or 30-60 mg IM | Acute pain management | Non-opioid analgesic (NSAID, parenteral) | Adult | IV/IM |
| Acute pain management#Ibuprofen Step 1 - Mild pain (NSAID) Adult | Ibuprofen | 400-800 mg PO q6-8h PRN | Acute pain management | Step 1 - Mild pain (NSAID) | Adult | PO |
| Acute pain management#Acetaminophen Step 1 - Mild pain (non-opioid) Adult | Acetaminophen | 650 mg PO q4-6h PRN or 1000 mg PO q6h PRN | Acute pain management | Step 1 - Mild pain (non-opioid) | Adult | PO |
| Acute pain management#Aspirin Step 1 - Mild pain (non-opioid) Adult | Aspirin | 650 mg PO q4-6h PRN or 1000 mg PO q6h PRN | Acute pain management | Step 1 - Mild pain (non-opioid) | Adult | PO |
| Acute pain management#Codeine Step 2 - Moderate pain (mild opioid) Adult | Codeine | 30-60 mg PO q3-4h | Acute pain management | Step 2 - Moderate pain (mild opioid) | Adult | PO |
| Acute pain management#Hydrocodone Step 2 - Moderate pain (mild opioid) Adult | Hydrocodone | 5-10 mg PO q4-6h PRN (with acetaminophen 325 mg) | Acute pain management | Step 2 - Moderate pain (mild opioid) | Adult | PO |
| Acute pain management#Oxycodone Step 2 - Moderate pain (mild opioid) Adult | Oxycodone | 5-10 mg PO q4-6h PRN | Acute pain management | Step 2 - Moderate pain (mild opioid) | Adult | PO |
| Acute pain management#Tramadol Step 2 - Moderate pain (mild opioid) Adult | Tramadol | 50-100 mg PO q4-6h | Acute pain management | Step 2 - Moderate pain (mild opioid) | Adult | PO |
| Acute pain management#Morphine Step 3 - Severe pain (1st line opioid) Adult | Morphine | 0.1 mg/kg IV or 10 mg IM or 0.3 mg/kg PO; titrate 2-5 mg IV q5-10min | Acute pain management | Step 3 - Severe pain (1st line opioid) | Adult | IV/IM/PO |
| Acute pain management#Butorphanol Step 3 - Severe pain (mixed agonist-antagonist) Adult | Butorphanol | 0.5-2.0 mg IV; average 2 mg q3-4h | Acute pain management | Step 3 - Severe pain (mixed agonist-antagonist) | Adult | IV |
| Acute pain management#Hydromorphone Step 3 - Severe pain (opioid) Adult | Hydromorphone | 0.015 mg/kg IV or 1-2 mg IM; titrate 0.5-1.0 mg IV increments | Acute pain management | Step 3 - Severe pain (opioid) | Adult | IV/IM |
| Acute pain management#Meperidine Step 3 - Severe pain (opioid, avoid if possible) Adult | Meperidine | 1.0-1.5 mg/kg IV/IM; titrate 12.5-50 mg IV increments | Acute pain management | Step 3 - Severe pain (opioid, avoid if possible) | Adult | IV/IM |
| Acute pain management#Fentanyl Step 3 - Severe pain (opioid, short-acting) Adult | Fentanyl | 1.0 mcg/kg IV; titrate 25-50 mcg IV q2-3min | Acute pain management | Step 3 - Severe pain (opioid, short-acting) | Adult | IV |
| Acute respiratory distress syndrome#Cisatracurium Neuromuscular blockade to prevent barotrauma/vent dyssynchrony Adult | Cisatracurium | 0.15mg/kg load, then 1-3mcg/kg/min | Acute respiratory distress syndrome | Neuromuscular blockade to prevent barotrauma/vent dyssynchrony | Adult | IV |
| Acute respiratory distress syndrome#Methylprednisolone Pulse-dose steroids for early established severe ARDS (Meduri protocol) Adult | Methylprednisolone | 1mg/kg load, then 1mg/kg/day (d1-14), taper over d15-28 | Acute respiratory distress syndrome | Pulse-dose steroids for early established severe ARDS (Meduri protocol) | Adult | IV |
| Acute rheumatic fever#Aspirin Anti-inflammatory for carditis/arthritis Pediatric | Aspirin | 50-100mg/kg/day PO divided q4-6h | Acute rheumatic fever | Anti-inflammatory for carditis/arthritis | Pediatric | PO |
| Acute rheumatic fever#Prednisone Moderate-to-severe carditis Pediatric | Prednisone | 1-2mg/kg/day PO | Acute rheumatic fever | Moderate-to-severe carditis | Pediatric | PO |
| Acute urinary retention#Tamsulosin Alpha-blocker for BPH-related retention (outpatient) Adult | Tamsulosin | 0.4mg QHS | Acute urinary retention | Alpha-blocker for BPH-related retention (outpatient) | Adult | PO |
| Agitated or combative patient#Droperidol 1st line antipsychotic for acute agitation Adult | Droperidol | 5 mg IM q5min x2 | Agitated or combative patient | 1st line antipsychotic for acute agitation | Adult | IM |
| Agitated or combative patient#Haloperidol Antipsychotic for acute agitation Adult | Haloperidol | 5-10 mg IM | Agitated or combative patient | Antipsychotic for acute agitation | Adult | IM |
| Agitated or combative patient#Olanzapine Atypical antipsychotic for agitation Adult | Olanzapine | 10 mg IM | Agitated or combative patient | Atypical antipsychotic for agitation | Adult | IM |
| Agitated or combative patient#Ziprasidone Atypical antipsychotic for agitation Adult | Ziprasidone | 20 mg IM | Agitated or combative patient | Atypical antipsychotic for agitation | Adult | IM |
| Agitated or combative patient#Lorazepam Benzodiazepine for agitation Adult | Lorazepam | 2 mg IV/IM | Agitated or combative patient | Benzodiazepine for agitation | Adult | IV/IM |
| Agitated or combative patient#Midazolam Benzodiazepine for agitation Adult | Midazolam | 5 mg IM | Agitated or combative patient | Benzodiazepine for agitation | Adult | IM |
| Agitated or combative patient#Ketamine Rescue sedation for severe agitation Adult | Ketamine | 4-6 mg/kg IM or 1 mg/kg IV | Agitated or combative patient | Rescue sedation for severe agitation | Adult | IM/IV |
| Akathisia#Benztropine Anticholinergic, first-line Adult | Benztropine | 1-2mg IV | Akathisia | Anticholinergic, first-line | Adult | IV |
| Akathisia#Diphenhydramine Anticholinergic, first-line Adult | Diphenhydramine | 50mg PO/IM/IV | Akathisia | Anticholinergic, first-line | Adult | PO/IM/IV |
| Aluminum phosphide poisoning#Magnesium sulfate Cardioprotective, may reduce mortality Adult | Magnesium sulfate | 4g IV over 20min, then 6g over 12hr infusion | Aluminum phosphide poisoning | Cardioprotective, may reduce mortality | Adult | IV |
| Aluminum phosphide poisoning#Sodium bicarbonate Correct metabolic acidosis Adult | Sodium bicarbonate | 1-2mEq/kg IV bolus, then infusion to maintain pH >7.2 | Aluminum phosphide poisoning | Correct metabolic acidosis | Adult | IV |
| Amanita mushrooms#N-Acetylcysteine Hepatoprotective, mortality benefit Adult | N-Acetylcysteine | 150mg/kg IV over 15min, then 50mg/kg over 4hr, then 100mg/kg over 16hr | Amanita mushrooms | Hepatoprotective, mortality benefit | Adult | IV |
| Amanita mushrooms#Penicillin G Inhibits amatoxin uptake Adult | Penicillin G | 1 million units/kg/day IV divided q4hr | Amanita mushrooms | Inhibits amatoxin uptake | Adult | IV |
| Angioedema#Epinephrine Allergic/anaphylactic angioedema Adult | Epinephrine | 0.3 mg IM | Angioedema | Allergic/anaphylactic angioedema | Adult | IM |
| Angioedema#Diphenhydramine Antihistamine (allergic angioedema) Adult | Diphenhydramine | 50 mg IV | Angioedema | Antihistamine (allergic angioedema) | Adult | IV |
| Angioedema#Icatibant Bradykinin B2 receptor antagonist (HAE/ACE-I angioedema) Adult | Icatibant | 30 mg SC | Angioedema | Bradykinin B2 receptor antagonist (HAE/ACE-I angioedema) | Adult | SC |
| Angioedema#Tranexamic acid Bradykinin-mediated angioedema (e.g., ACE-I induced) Adult | Tranexamic acid | 1 g IV over 10 min | Angioedema | Bradykinin-mediated angioedema (e.g., ACE-I induced) | Adult | IV |
| Angioedema#Methylprednisolone Corticosteroid (allergic angioedema) Adult | Methylprednisolone | 125 mg IV | Angioedema | Corticosteroid (allergic angioedema) | Adult | IV |
| Angioedema#Glucagon If on beta-blockers and not responding to epinephrine Adult | Glucagon | 1-5 mg IV | Angioedema | If on beta-blockers and not responding to epinephrine | Adult | IV |
| Angioedema#Ecallantide Kallikrein inhibitor (HAE) Adult | Ecallantide | 10 mg SC x3 at different sites (30 mg total) | Angioedema | Kallikrein inhibitor (HAE) | Adult | SC |
| Anticoagulant reversal for life-threatening bleeds#Idarucizumab Dabigatran reversal Adult | Idarucizumab | 5g IV | Anticoagulant reversal for life-threatening bleeds | Dabigatran reversal | Adult | IV |
| Anticoagulant reversal for life-threatening bleeds#Protamine Heparin/LMWH reversal Adult | Protamine sulfate | 50mg IV (<8hr since last dose), 25mg (8-12hr) | Anticoagulant reversal for life-threatening bleeds | Heparin/LMWH reversal | Adult | IV |
| Anticoagulant reversal for life-threatening bleeds#Vitamin K Warfarin reversal with life-threatening bleed (INR >10) Adult | Vitamin K | 10mg IV over 30min | Anticoagulant reversal for life-threatening bleeds | Warfarin reversal with life-threatening bleed (INR >10) | Adult | IV |
| Antipsychotic toxicity#Diphenhydramine Dystonic reaction Adult | Diphenhydramine | 25-50mg IV/IM | Antipsychotic toxicity | Dystonic reaction | Adult | IV/IM |
| Antipsychotic toxicity#Benztropine Dystonic reaction, alternative Adult | Benztropine | 1-2mg IV/IM | Antipsychotic toxicity | Dystonic reaction, alternative | Adult | IV/IM |
| Antipsychotic toxicity#Magnesium sulfate QTc >500ms Adult | Magnesium sulfate | 2-4g IV over 10 min | Antipsychotic toxicity | QTc >500ms | Adult | IV |
| Atrial fibrillation (main)#Apixaban Anticoagulation (NOAC) Adult | Apixaban | 5 mg BID (reduced: 2.5 mg BID if ≥2 of: age ≥80, wt ≤60 kg, Cr ≥1.5) | Atrial fibrillation (main) | Anticoagulation (NOAC) | Adult | PO |
| Atrial fibrillation (main)#Dabigatran Anticoagulation (NOAC) Adult | Dabigatran | 150 mg BID (reduced: 75 mg BID if CrCl 15-30) | Atrial fibrillation (main) | Anticoagulation (NOAC) | Adult | PO |
| Atrial fibrillation (main)#Edoxaban Anticoagulation (NOAC) Adult | Edoxaban | 60 mg daily (reduced: 30 mg daily if CrCl 15-50 or wt ≤60 kg) | Atrial fibrillation (main) | Anticoagulation (NOAC) | Adult | PO |
| Atrial fibrillation (main)#Rivaroxaban Anticoagulation (NOAC) Adult | Rivaroxaban | 20 mg daily with evening meal (reduced: 15 mg daily if CrCl 15-50) | Atrial fibrillation (main) | Anticoagulation (NOAC) | Adult | PO |
| Atrial fibrillation (main)#Diltiazem Rate control (1st line CCB) Adult | Diltiazem | 0.25-0.35 mg/kg IV (typical 20 mg), then 25 mg IV if needed; followed by 60-120 mg PO or drip | Atrial fibrillation (main) | Rate control (1st line CCB) | Adult | IV/PO |
| Atrial fibrillation (main)#Metoprolol Rate control (1st line beta-blocker) Adult | Metoprolol | 5 mg IV q5min x3 | Atrial fibrillation (main) | Rate control (1st line beta-blocker) | Adult | IV |
| Atrial fibrillation (main)#Digoxin Rate control (if hypotensive or advanced HF) Adult | Digoxin | 500 mcg IV, then 250 mcg q4h x2 (total 1000 mcg digitizing dose) | Atrial fibrillation (main) | Rate control (if hypotensive or advanced HF) | Adult | IV |
| Atrial fibrillation (main)#Procainamide Rhythm control (Ottawa aggressive protocol) Adult | Procainamide | 1 g IV over 60 min (Ottawa protocol); hold if SBP <100 | Atrial fibrillation (main) | Rhythm control (Ottawa aggressive protocol) | Adult | IV |
| Atrial fibrillation (main)#Amiodarone Rhythm control (if hypotension or advanced HF) Adult | Amiodarone | 150 mg IV over 10 min, then 1 mg/min x6h, then 0.5 mg/min x18h | Atrial fibrillation (main) | Rhythm control (if hypotension or advanced HF) | Adult | IV drip |
| Atrial fibrillation with RVR#Magnesium sulfate Adjunctive rate control Adult | Magnesium sulfate | 2g over 1-5min; repeat after 15min if no response; then 1-2g/hr x 4hr | Atrial fibrillation with RVR | Adjunctive rate control | Adult | IV |
| Atrial fibrillation with RVR#Diltiazem First-line rate control (CCB) Adult | Diltiazem | 0.25mg/kg (max 20mg) IV over 2min; repeat 0.35mg/kg after 15min; drip 5-20mg/hr | Atrial fibrillation with RVR | First-line rate control (CCB) | Adult | IV |
| Atrial fibrillation with RVR#Metoprolol Rate control (beta-blocker) Adult | Metoprolol | 5mg IV q5min x3 | Atrial fibrillation with RVR | Rate control (beta-blocker) | Adult | IV |
| Atrial fibrillation with RVR#Esmolol Rate control (beta-blocker); easily titratable Adult | Esmolol | 0.5mg/kg bolus over 1min, then 50-200mcg/kg/min | Atrial fibrillation with RVR | Rate control (beta-blocker); easily titratable | Adult | IV |
| Atrial fibrillation with RVR#Amiodarone Unstable AF; rate/rhythm control when other agents fail Adult | Amiodarone | 150mg over 10min, up to 6 doses | Atrial fibrillation with RVR | Unstable AF; rate/rhythm control when other agents fail | Adult | IV |
| Atrial flutter#Procainamide Preexcited atrial flutter Adult | Procainamide | 20-50 mg/min until arrhythmia controlled | Atrial flutter | Preexcited atrial flutter | Adult | IV |
| Atrial flutter#Diltiazem Rate control Adult | Diltiazem | 2.5 mg/min until HR <100 (max 50 mg) | Atrial flutter | Rate control | Adult | IV |
| Atrial flutter#Amiodarone Rate control (alternative) Adult | Amiodarone | 150 mg over 10 min | Atrial flutter | Rate control (alternative) | Adult | IV |
| Benzodiazepine toxicity#Flumazenil Benzodiazepine antagonist (controversial) Adult | Flumazenil | 0.2 mg IV, repeat q1min | Benzodiazepine toxicity | Benzodiazepine antagonist (controversial) | Adult | IV |
| Beriberi#Thiamine Thiamine replacement Adult | Thiamine | 50-100mg IV/IM daily x 7-14 days, then 10mg PO daily until recovery | Beriberi | Thiamine replacement | Adult | IV/IM |
| Beta-blocker toxicity#Calcium chloride Calcium supplementation Adult | Calcium chloride | 1-3 g IV (10-20 mL 10% solution) | Beta-blocker toxicity | Calcium supplementation | Adult | IV |
| Beta-blocker toxicity#Insulin High-dose insulin euglycemic therapy Adult | Insulin | 1 unit/kg IV bolus with D50, then 0.5-1 unit/kg/hr drip | Beta-blocker toxicity | High-dose insulin euglycemic therapy | Adult | IV/IV drip |
| Beta-blocker toxicity#Intralipid Lipid emulsion therapy Adult | Intralipid | 1.5 mL/kg IV bolus of 20%, then 0.25 mL/kg/min for 30-60 min | Beta-blocker toxicity | Lipid emulsion therapy | Adult | IV/IV drip |
| Beta-blocker toxicity#Glucagon Positive inotrope/chronotrope (acts independently of beta receptors) Adult | Glucagon | 5 mg IV bolus over 1 min (adult); 50 mcg/kg (pediatric); repeat in 10 min if no response; then drip 2-5 mg/hr | Beta-blocker toxicity | Positive inotrope/chronotrope (acts independently of beta receptors) | Adult | IV/IV drip |
| Beta-blocker toxicity#Glucagon Positive inotrope/chronotrope (pediatric) Pediatric | Glucagon | 50 mcg/kg IV bolus; then 70 mcg/kg/hr drip | Beta-blocker toxicity | Positive inotrope/chronotrope (pediatric) | Pediatric | IV/IV drip |
| Beta-blocker toxicity#Atropine Symptomatic bradycardia (initial) Adult | Atropine | 0.5-1 mg IV q3-5min (max 3 mg) | Beta-blocker toxicity | Symptomatic bradycardia (initial) | Adult | IV |
| Body packing#Naloxone Opioid packet rupture Adult | Naloxone | 2-5mg IV initially, repeat 2mg q5min until responsive; then continuous infusion at total response dose/hr | Body packing | Opioid packet rupture | Adult | IV |
| COPD exacerbation#Hydrocortisone Corticosteroid (IV option) Adult | Hydrocortisone topical | 100-125 mg IV q6h x5 days | COPD exacerbation | Corticosteroid (IV option) | Adult | IV |
| COPD exacerbation#Methylprednisolone Corticosteroid (IV option) Adult | Methylprednisolone | 125 mg IV daily (1-2 mg/kg) | COPD exacerbation | Corticosteroid (IV option) | Adult | IV |
| COPD exacerbation#Prednisone Corticosteroid (preferred, oral) Adult | Prednisone | 60 mg PO x1, then 40 mg PO daily x5 days | COPD exacerbation | Corticosteroid (preferred, oral) | Adult | PO |
| Calcium channel blocker toxicity#Glucagon Adjunct for bradycardia/hypotension Adult | Glucagon | 5 mg IV bolus q10min x2 | Calcium channel blocker toxicity | Adjunct for bradycardia/hypotension | Adult | IV |
| Calcium channel blocker toxicity#Calcium gluconate Calcium supplementation Adult | Calcium gluconate | 3 g (30-60 mL of 10% solution) IV bolus | Calcium channel blocker toxicity | Calcium supplementation | Adult | IV |
| Calcium channel blocker toxicity#Calcium chloride Calcium supplementation (preferred, 3x calcium vs gluconate) Adult | Calcium chloride | 1-3 g IV bolus (10-20 mL 10% solution), then 1 g IV q5min to BP effect; drip 10-50 mg/kg/hr | Calcium channel blocker toxicity | Calcium supplementation (preferred, 3x calcium vs gluconate) | Adult | IV/IV drip |
| Calcium channel blocker toxicity#Insulin High-dose insulin euglycemic therapy (best evidence) Adult | Insulin | 1 unit/kg IV bolus with D50, then 0.5-1 unit/kg/hr drip (max 2 units/kg/hr) | Calcium channel blocker toxicity | High-dose insulin euglycemic therapy (best evidence) | Adult | IV/IV drip |
| Calcium channel blocker toxicity#Intralipid Lipid emulsion therapy Adult | Intralipid | 1.5 mL/kg IV bolus of 20% lipid, then 0.25 mL/kg/min | Calcium channel blocker toxicity | Lipid emulsion therapy | Adult | IV/IV drip |
| Calcium channel blocker toxicity#Atropine Symptomatic bradycardia Adult | Atropine | 0.5-1 mg IV q2-3min (max 3 mg) | Calcium channel blocker toxicity | Symptomatic bradycardia | Adult | IV |
| Calcium channel blocker toxicity#Atropine Symptomatic bradycardia (pediatric) Pediatric | Atropine | 0.02 mg/kg IV (min 0.1 mg) | Calcium channel blocker toxicity | Symptomatic bradycardia (pediatric) | Pediatric | IV |
| Calcium channel blocker toxicity#Norepinephrine Vasopressor (agent of choice) Adult | Norepinephrine | Start 2 mcg/min, uptitrate rapidly to MAP ≥65 | Calcium channel blocker toxicity | Vasopressor (agent of choice) | Adult | IV drip |
| Cannabinoid hyperemesis syndrome#Diphenhydramine Adjunct with haloperidol Adult | Diphenhydramine | 50mg IV | Cannabinoid hyperemesis syndrome | Adjunct with haloperidol | Adult | IV |
| Cannabinoid hyperemesis syndrome#Haloperidol Antiemetic, first-line Adult | Haloperidol | 5mg IV or IM | Cannabinoid hyperemesis syndrome | Antiemetic, first-line | Adult | IV/IM |
| Cannabinoid hyperemesis syndrome#Lorazepam Anxiolytic/antiemetic Adult | Lorazepam | 1-2mg IV | Cannabinoid hyperemesis syndrome | Anxiolytic/antiemetic | Adult | IV |
| Carbamate poisoning#Atropine Antimuscarinic, first-line Adult | Atropine | 1-2mg IV, double dose q5min until drying of secretions | Carbamate poisoning | Antimuscarinic, first-line | Adult | IV |
| Carbamate poisoning#Atropine Antimuscarinic, first-line Pediatric | Atropine | 0.02-0.05mg/kg IV (min 0.1mg), double q5min until drying of secretions | Carbamate poisoning | Antimuscarinic, first-line | Pediatric | IV |
| Carbamate poisoning#Pralidoxime Only if unknown agent or mixed OP/carbamate exposure Adult | Pralidoxime | 20mg/kg (max 2g) IV over 30min, then 8-10mg/kg/hr (max 650mg/hr) | Carbamate poisoning | Only if unknown agent or mixed OP/carbamate exposure | Adult | IV |
| Carbamate poisoning#Diazepam Seizure control Adult | Diazepam | 5-10mg IV | Carbamate poisoning | Seizure control | Adult | IV |
| Carbamate poisoning#Diazepam Seizure control Pediatric | Diazepam | 0.2-0.5mg/kg IV | Carbamate poisoning | Seizure control | Pediatric | IV |
| Carbamate toxicity#Pralidoxime Cholinergic toxicity (oxime reactivator) Adult | Pralidoxime | 1-2 g IV over 15-30 min, then 8-10 mg/kg/hr infusion (or repeat bolus in 1 hr) | Carbamate toxicity | Cholinergic toxicity (oxime reactivator) | Adult | IV |
| Carbamate toxicity#Pralidoxime Cholinergic toxicity (oxime reactivator) Pediatric | Pralidoxime | 20-50 mg/kg IV, then 5-10 mg/kg/hr infusion | Carbamate toxicity | Cholinergic toxicity (oxime reactivator) | Pediatric | IV |
| Carbamate toxicity#Atropine Cholinergic toxicity antidote (muscarinic) Pediatric | Atropine | 0.02-0.05 mg/kg IV (min 0.1 mg), double q5min | Carbamate toxicity | Cholinergic toxicity antidote (muscarinic) | Pediatric | IV |
| Carbamate toxicity#Atropine Cholinergic toxicity antidote (muscarinic) Adult | Atropine | 1-2 mg IV (double q5min until atropinization) | Carbamate toxicity | Cholinergic toxicity antidote (muscarinic) | Adult | IV |
| Cesium toxicity#Magnesium sulfate First-line for QTc prolongation Adult | Magnesium sulfate | 2g IV bolus | Cesium toxicity | First-line for QTc prolongation | Adult | IV |
| Chloramine#Dexamethasone Airway inflammation Adult | Dexamethasone | 0.6mg/kg IV or PO (max 16mg) | Chloramine | Airway inflammation | Adult | IV/PO |
| Chloramine#Methylprednisolone Airway inflammation Adult | Methylprednisolone | 125mg IV (adults); 2mg/kg IV (children) | Chloramine | Airway inflammation | Adult | IV |
| Chloramine#Albuterol Bronchospasm Adult | Albuterol | 2.5-5mg nebulized q20min or continuous | Chloramine | Bronchospasm | Adult | Nebulized |
| Cholinergic crisis#Atropine Antimuscarinic, first-line Adult | Atropine | 2-4mg IV q5min, titrate to resolution of bronchorrhea; then infusion at 10% of loading dose/hr | Cholinergic crisis | Antimuscarinic, first-line | Adult | IV |
| Cholinergic crisis#Pralidoxime Cholinesterase reactivator Adult | Pralidoxime | 20mg/kg (max 2g) IV over 30min, then 8-10mg/kg/hr (max 650mg/hr) | Cholinergic crisis | Cholinesterase reactivator | Adult | IV |
| Cholinergic crisis#Lorazepam Seizure control Adult | Lorazepam | 2-4mg IV | Cholinergic crisis | Seizure control | Adult | IV |
| Clonidine toxicity#Atropine Bradycardia Adult | Atropine | 0.5-1 mg | Clonidine toxicity | Bradycardia | Adult | IV |
| Clonidine toxicity#Naloxone CNS/respiratory depression reversal Adult | Naloxone | 0.4-2 mg IV, may repeat up to 10 mg | Clonidine toxicity | CNS/respiratory depression reversal | Adult | IV |
| Coarctation of the aorta#Furosemide CHF management Pediatric | Furosemide | 1-2mg/kg IV | Coarctation of the aorta | CHF management | Pediatric | IV |
| Coarctation of the aorta#Prostaglandin E1 Duct-dependent lesion, maintain PDA patency Pediatric | Prostaglandin E1 | 0.1mcg/kg/min IV/IO | Coarctation of the aorta | Duct-dependent lesion, maintain PDA patency | Pediatric | IV/IO |
| Coarctation of the aorta#Dobutamine Inotropic support for CHF Pediatric | Dobutamine | 5-10mcg/kg/min IV | Coarctation of the aorta | Inotropic support for CHF | Pediatric | IV |
| Coarctation of the aorta#Dopamine Inotropic support for CHF Pediatric | Dopamine | 5-10mcg/kg/min IV | Coarctation of the aorta | Inotropic support for CHF | Pediatric | IV |
| Cocaine toxicity#Phentolamine Direct alpha-antagonist for refractory hypertension Adult | Phentolamine | 2.5-5mg IV | Cocaine toxicity | Direct alpha-antagonist for refractory hypertension | Adult | IV |
| Cocaine toxicity#Diazepam First-line for agitation, seizures, and sympathetic excess Adult | Diazepam | 5-10mg IV q5min PRN agitation | Cocaine toxicity | First-line for agitation, seizures, and sympathetic excess | Adult | IV |
| Congenital heart disease#Prostaglandin E1 Duct-dependent lesions, maintain PDA patency Pediatric | Prostaglandin E1 | 0.1mcg/kg/min IV/IO | Congenital heart disease | Duct-dependent lesions, maintain PDA patency | Pediatric | IV/IO |
| Congenital heart disease#Phenylephrine Tet spell (TOF), increase SVR Pediatric | Phenylephrine | 2-10mcg/kg/min IV infusion | Congenital heart disease | Tet spell (TOF), increase SVR | Pediatric | IV |
| Congenital heart disease#Propranolol Tet spell (TOF), relieves infundibular spasm Pediatric | Propranolol | 0.2mg/kg IV | Congenital heart disease | Tet spell (TOF), relieves infundibular spasm | Pediatric | IV |
| Congestive heart failure#Enalaprilat ACE inhibitor for afterload reduction Adult | Enalaprilat | 0.004 mg/kg IV bolus or 1 mg IV drip over 2 hours | Congestive heart failure | ACE inhibitor for afterload reduction | Adult | IV |
| Congestive heart failure#Nitroprusside Afterload reduction (if HTN or NTG ineffective) Adult | Nitroprusside | 0.3 mcg/kg/min IV drip | Congestive heart failure | Afterload reduction (if HTN or NTG ineffective) | Adult | IV drip |
| Congestive heart failure#Furosemide Diuresis (hold if no fluid overload; give nitrates first) Adult | Furosemide | Double home dose IV or up to 2.5x dose (e.g., if 40 mg PO daily → 40-100 mg IV) | Congestive heart failure | Diuresis (hold if no fluid overload; give nitrates first) | Adult | IV |
| Congestive heart failure#Dobutamine Inotrope (1st line for hypotensive HF) Adult | Dobutamine | 2-20 mcg/kg/min IV drip | Congestive heart failure | Inotrope (1st line for hypotensive HF) | Adult | IV drip |
| Congestive heart failure#Milrinone Inotrope (if on beta-blockers) Adult | Milrinone | 0.375-0.75 mcg/kg/min IV drip | Congestive heart failure | Inotrope (if on beta-blockers) | Adult | IV drip |
| Congestive heart failure#Nitroglycerin Preload/afterload reduction (1st line for hypertensive HF) Adult | Nitroglycerin | 0.4 mg SL q5min x3; or IV drip start 10-20 mcg/min, titrate to BP (keep >95) | Congestive heart failure | Preload/afterload reduction (1st line for hypertensive HF) | Adult | SL/IV drip |
| Copper sulfate toxicity#Dimercaprol Chelation, first-line for severe Adult | Dimercaprol | 3-5mg/kg/dose IM q4hr x 2 days, then taper over 7-11 days | Copper sulfate toxicity | Chelation, first-line for severe | Adult | IM |
| Copper sulfate toxicity#Penicillamine Oral chelation Adult | Penicillamine | 1-1.5g/day PO in 2-4 divided doses | Copper sulfate toxicity | Oral chelation | Adult | PO |
