- Caffeine dependence and withdrawal is very common
- Up to 52% of moderate caffeine uses have withdrawal symptoms
Common Dosages by Type
^Average caffeine content can vary
- Most common symptoms
- Decreased energy/activeness
- Decreased alertness
- Decreased contentedness
- Depressed mood
- Difficulty concentrating, irritability, and foggy/not clearheaded
- Additional symptoms
- Flu-like symptoms
- Muscle pain/stiffness
- History should can be sufficient
- Consider further workup in ambiguous cases
- OTC analgesics
- Rule out more serious etiologies
- Onset 12–24 h after abstinence
- Peak intensity at 20–51 h
- Duration of 2–9 days
- ↑ Silverman K, et al. Withdrawal syndrome after the double-blind cessation of caffeine consumption. NEJM. 1992; 327(16):1109–1114.
- ↑ Food Standards Agency (2001) Statement on the Reproductive Effects of Caffeine. London: Food Standards Agency.
- ↑ Juliano LM and Griffiths RR. Caffeine. In Lowinson, J.H., Ruiz, P., Millman, R.B., Langrod, J.G. (Eds.). Substance Abuse: A Comprehensive Textbook, Fourth Edition. 2005. PP. 403-421. Baltimore: Lippincott, Williams, & Wilkins.
- ↑ Juliano LM and Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features . Psychopharmacology. 2008; 176(1):1–29.