- Strong acid, causes coagulation necrosis due to denaturation of proteins
- Most household bleaches are only 3-6% hydrochlorite solutions, but patients may have occupational exposures if working in steel picking, chemical manufacturing, oil/gas-well acidizing, and food processing
- HCl is combustion product of polyvinyl chloride (PVC), can cause chemical inhalation injury, can persist in air for up to an hour after fire extinguished
- Can be systemically absorbed and → metabolic acidosis, hemolysis, AKI
- Dermal caustic burns
- inhalation injury
- Caustic keratoconjunctivitis
- Caustic ingestion
- Caustic eye exposure (Caustic keratoconjunctivitis)
- Caustic dermal burn
- Airbag-related burns
- Hydrofluoric acid
- Tar burn
- Cement burn
- Clinical diagnosis
- Only necessary in patients with significant injury or volume of ingestion
- CBC, metabolic panel, lactate, serum calcium (if concern for hydrofluoric acid exposure
- Tylenol/ASA levels if concerned about coingestion (suicidal patients)
- Ingestion, consider:
- 3-View CXR: look for free air under diaphragm or mediastinal free air
- CT: if suspect perforation but CXR negative
- Decontaminate first: use appropriate personal protective equipment, remove all patient's clothing, decontaminate patient
- Irrigate areas of dermal or ocular exposure, early and copiously!
- Airway management
- Monitor closely for stridor, airway edema, hoarseness, or other signs of airway injury
- Intubate early if signs of airway injury exist, before airway becomes more difficult to manage.
- Consider awake fiberoptic or video laryngoscopy if concern for difficult airway
- Blind nasotracheal intubation is contraindicated in caustic ingestion due to the potential for perforations and false passages
- Bronchodilators for bronchospasm if concern for inhalational injury
- Metabolic acidosis: consider bicarbonate for severe acidosis
- Severe hemolysis may require exchange transfusion
- Airway management especially important!
- Perform within 12-24 hours of ingestion (too early can underestimate extent of injury, too late increases risk of wound softening and perforation)
- Esophageal stricture mitigation
- Surgical intervention: indicated if perforation or peritoneal signs
- Contraindicated (or controversial) therapies:
- Antibiotics (unless giving steroids]]
- Activated charcoal (may consider when coingestants pose a risk for severe systemic toxicity)
- Gastric lavage: contraindicated due to potential to cause reflux of caustic agent into esophagus, creating more damage
- Dilution with water or milk: causes vomiting, elevating risk for perforation
- Neutralization (e.g. with milk or mag citrate): generates excess heat
- Eye irrigation
- Immediate irrigation is the most important treatment for caustic ocular injury, and should be started before comprehensive evaluation
- Irrigate affected eye(s) with copious amounts of fluid (no consensus on volume or length of time)
- NS, LR, or BSS (Buffered Saline Solution) preferred in the hospital setting, but tap water is acceptable, especially in pre-hospital setting.
- Goal is to remove caustic agent and restore normal ocular pH (7.0-7.2)
- Do NOT attempt to neutralize pH by adding base to an acidic burn or acid to an alkali burn
- Use of morgan lens or eyelid speculum will assist with getting more fluid in contact with cornea
- Remove particulate matter
- Evert both lids, remove any visible particulate matter with cotton-tipped applicator
- Control inflammation
- Ophthalmology consultation for all but minor burns (Severe exposures may require debridement or other surgical intervention)
- Dependant on severity of exposure and complications
- High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns. Pediatrics 2014;133:e1518–e1524
- Chau JP, Lee DT, Lo SH. A systematic review of methods of eye irrigation for adults and children with ocular chemical burns. Worldviews Evid Based Nurs. 2012 Aug;9(3):129-38.
- Herr RD, White GL Jr, Bernhisel K, Mamalis N, Swanson E. Clinical comparison of ocular irrigation fluids following chemical injury. Am J Emerg Med. 1991 May;9(3):228-31.
- Dohlman, C.H., F. Cade, and R. Pfister, Chemical burns to the eye: paradigm shifts in treatment. Cornea, 2011. 30(6): p. 613-4.
- Donshik, P.C., et al., Effect of topical corticosteroids on ulceration in alkali-burned corneas. Archives of ophthalmology, 1978. 96(11): p. 2117-20.